144432-85-9 Usage
Description
3-Chloro-4-fluorophenylboronic acid is an organic compound with the chemical formula C6H4ClFO2B. It is an off-white to faintly orange powder and is commonly used as a reactant in various chemical reactions due to its unique chemical properties.
Uses
1. Used in Suzuki Reaction:
3-Chloro-4-fluorophenylboronic acid is used as a reactant in the Suzuki reaction, a type of palladium-catalyzed cross-coupling reaction. This reaction is widely employed in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries.
2. Used in Rh-catalyzed Asymmetric Addition Reactions:
In the field of asymmetric catalysis, 3-Chloro-4-fluorophenylboronic acid serves as a reactant for Rh-catalyzed asymmetric addition reactions. These reactions are crucial in the synthesis of enantiomerically pure compounds, which are essential in the development of pharmaceuticals and agrochemicals.
3. Used in Palladium-catalyzed Oxidative Cross-coupling Reaction:
3-Chloro-4-fluorophenylboronic acid is also utilized as a reactant in palladium-catalyzed oxidative cross-coupling reactions. These reactions are significant in the formation of carbon-carbon and carbon-heteroatom bonds, which are vital in the synthesis of complex organic molecules.
4. Used in the Synthesis of 2-Bromo-3-Hexyl-5-(4-Iodophenyl)thiophene:
3-Chloro-4-fluorophenylboronic acid has been used in the synthesis of 2-bromo-3-hexyl-5-(4-iodophenyl)thiophene, a compound that has demonstrated high anti-thrombolytic activity. This application is particularly relevant in the pharmaceutical industry for the development of new drugs to treat thrombolytic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 144432-85-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,3 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 144432-85:
(8*1)+(7*4)+(6*4)+(5*4)+(4*3)+(3*2)+(2*8)+(1*5)=119
119 % 10 = 9
So 144432-85-9 is a valid CAS Registry Number.
144432-85-9Relevant articles and documents
An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids
Li, Wenjie,Nelson, Dorian P.,Jensen, Mark S.,Hoerrner, R. Scott,Cai, Dongwei,Larsen, Robert D.,Reider, Paul J.
, p. 5394 - 5397 (2002)
3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.
