60811-21-4

Basic information

• Product Name: 4-Bromo-2-chloro-1-fluorobenzene
• Synonyms: 3-Chloro-4-fluorobromobenzene 98%;3-chloro-4-fluorobroMobezene;4-BroMo-2-chloro-1-fluorobenzene, 99.5%;4-BroMo-2-chloro-1-fluorobenzene, 99.5%, 99.5%;3-chloro-4-fluoro-5-bromo-2-fluoro-bromobenzene chlorobenzene;AKOS 91987;3-CHLORO-4-FLUOROBENZENE BROMIDE;3-CHLORO-4-FLUOROBROMOBENZENE
• CAS NO: 60811-21-4
• Molecular Formula: C₆H₃BrClF
• Molecular Weight: 209.44
• EINECS: 405-580-2
• Product Categories: Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series;Aromatic Halides (substituted);Fluorobenzene;Bromine Compounds;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorinated benzene series
• Mol File: 60811-21-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 194 °C(lit.)
• Flash Point: 192 °F
• Appearance: clear yellow liquid
• Density: 1.727 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.56mmHg at 25°C
• Refractive Index: n20/D 1.553(lit.)
• BRN: 2206652
• CAS DataBase Reference: 4-Bromo-2-chloro-1-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-chloro-1-fluorobenzene(60811-21-4)
• EPA Substance Registry System: 4-Bromo-2-chloro-1-fluorobenzene(60811-21-4)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 22-38-50/53
• Safety Statements: 26-36/37-60-61
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 3
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 60811-21-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 60811-21-4 differently. You can refer to the following data:
1. 4-Bromo-2-chloro-1-fluorobenzene may be used for the preparation of 2-(3-chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
2. Intermediates of Liquid Crystals

InChI:InChI=1/C6H3BrClF/c7-4-1-2-6(9)5(8)3-4/h1-3H

Upstream product

• 367-21-5 3-chloro-4-fluorophenylamine 

Downstream Products

• 144432-85-9 3-chloro-4-fluorophenylboronic acid 
• 304854-45-3 6-(3-Chloro-4-fluoro-phenyl)-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 121626-73-1 3-(3-chloro-4-fluorophenyl)propene 
• 915001-95-5 (S)-3-(3-chloro-4-fluorophenylamino)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 749929-86-0 2-(4-Bromo-2-chloro-phenyl)-2-methyl-propionitrile 
• 1225276-17-4 tert-butyl 2-(3-chloro-4-fluorophenyl)-2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate 
• 716359-69-2 t-butyl 4-(3-chloro-4-fluorophenyl)-4-(1-cyano-2-ethoxy-2-oxoethyl)piperidine-1-carboxylate 
• 1315380-40-5 (3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 
• 1315380-39-2 (R)-5-((3-Chloro-4-fluorophenyl)(hydroxy)methyl)-N,3-dihydroxy-4-(hydroxymethyl)picolinamide 
• 1315380-42-7 (3-Chloro-4-fluorophenyl)(2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanone 
• 1315380-43-8 5-(3-Chloro-4-fluorobenzoyl)-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine 7-oxide 
• 1315380-44-9 (3-Chloro-4-fluorophenyl)(8-(hydroxymethyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanone 
• 1315380-45-0 5-(3-Chloro-4-fluorobenzoyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde 
• 1315380-46-1 methyl 5-(3-Chloro-4-fluorobenzoyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate 

Relevant articles and documents

Process for the preparation of (aryl)-(dimethyl)-(3-(4-fluoro-3-aryloxyphenyl)propyl)silanes

The present invention relates to a process for the preparation of compounds of the formula I STR1 in which R1 denotes H, halogen, (C1 -C4)-alkyl or (C1 -C4)-alkoxy and R2 denotes H, halogen, (C1 -C4)-alkyl, (C1 -C4)-alkyl-thio, (C1 -C4)-alkoxy or the bivalent group 3,4-0-CH2 -O, comprising reacting a compound of the formula II STR2 in which X denotes halogen and R2 has the meaning as in formula I, in the presence of a copper catalyst with an alkali metal phenolate or alkaline earth metal phenolate of the formula III STR3 in which M denotes an alkali metal or an alkaline earth metal and R1 has the meaning as in formula I.