1470-94-6

Basic information

• Product Name: 5-INDANOL
• Synonyms: 2,3-dihydro-1h-inden-5-o;Indanol-5;INDAN-5-OL;5-INDANOL;5-HYDROXYHYDRINDENE;5-HYDROXYINDAN;1H-Inden-5-ol, 2,3-dihydro-;Indan-5-ol 98%
• CAS NO: 1470-94-6
• Molecular Formula: C₉H₁₀O
• Molecular Weight: 134.18
• EINECS: 216-006-3
• Product Categories: Indane/Indanone and Derivatives
• Mol File: 1470-94-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 51-53 °C(lit.)
• Boiling Point: 255 °C(lit.)
• Flash Point: >230 °F
• Appearance: slightly brown/
• Density: 0.8540 (rough estimate)
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.5630 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 6.3g/l
• PKA: 10.37±0.20(Predicted)
• BRN: 1936314
• CAS DataBase Reference: 5-INDANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-INDANOL(1470-94-6)
• EPA Substance Registry System: 5-INDANOL(1470-94-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 21-20/21/22
• Safety Statements: 36/37-36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: NK7525000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1470-94-6(Hazardous Substances Data)

Usage

Uses

5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin; a compound which has been shown to reduce blood pressure in mammals and also has been used as a β-lactam antibiotic.

Chemical Properties

light brown to grey-brown crystalline powder or

Definition

ChEBI: A member of the class of phenols that is indan which has been hydroxylated at position 5.

Purification Methods

Crystallise 5-hydroxyindane from pet ether (m 56o) or pentane (m 59-60o). It has UV with max at 283.5nm (cyclohexane). The 3,5-dinitrobenzoyl derivative has m 156o. [Beilstein 6 III 2428, 6 IV 3829.]

InChI:InChI=1/C9H10O/c10-9-5-4-7-2-1-3-8(7)6-9/h4-6,10H,1-3H2

Upstream product

• 1045730-02-6 C₁₀H₁₂O₃ 
• 55153-56-5 7a-Methoxy-1,2,3,7a-tetrahydro-inden-5-one 
• 496-11-7 INDANE 
• 143287-97-2 2,3-dihydro-1H-inden-5-yl trifluoromethanesulfonate 
• 5111-69-3 5-methoxyindane 
• 945546-33-8 6-oxo-1,2,3,6-tetrahydroindene-3a-carboxylic acid tert-butyl ester 
• 77202-23-4 3a-hydroxy-6-(phenylthio)hexahydro-5-indanone 
• 24425-40-9 indan-5-amine 
• 3470-49-3 5-hydroxy-2,3-dihydro-1H-indene-1-one 

Downstream Products

• 132048-42-1 6-(3,4-dichloro-benzyl)-indan-5-ol 
• 112322-13-1 4,6-bis-(3,4-dichloro-benzyl)-indan-5-ol 
• 5440-82-4 acetic acid indan-5-ylester 
• 35141-78-7 3-benzyl-2,3,4,6,7,8-hexahydro-indeno[5,6-e][1,3]oxazine 
• 69183-04-6 {4-[3-(4-Chloro-phenoxy)-propoxy]-phenyl}-(indan-5-yloxy)-acetic acid methyl ester 
• 69182-92-9 {4-[2-(4-tert-Butyl-phenoxy)-ethoxy]-phenyl}-(indan-5-yloxy)-acetic acid methyl ester 
• 55505-13-0 (Indan-5-yloxysulfonyl)-phenyl-acetic acid 
• 3716-38-9 Hydrindanol-(5) 
• 3716-38-9 cis-bicyclo<4.3.0>nonan-3-ol 
• 91496-98-9 2-(Indan-5-yloxy)-propionic acid 
• 142626-61-7 5-(2-methylbenzoyloxy)indan 
• 1623-09-2 6-tert-butyl-5-indanol 
• 5111-69-3 5-methoxyindane 
• 101773-24-4 5-allyl-1,2,3-trimethylbenzene 

Relevant articles and documents

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CYCLIC PEROXIDE OXIDATION OF AROMATIC COMPOUND PRODUCTION AND USE THEREOF

The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C-H bonds; oxidizing selectively one of the one or more aromatic C-H bonds in preference to the one or more activated C-H bonds; adding a hydroxyl group to the one of the one or more aromatic C-H bonds to form one or more phenols; and purifying the one or more phenols.

Reactions of triflate esters and triflamides with an organic neutral super-electron-donor

The bis-pyridinylidene 13 converts aliphatic and aryl triflate esters to the corresponding alcohols and phenols respectively, using DMF as solvent, generally in excellent yields. While the deprotection of aryl triflates has been seen with other reagents and by more than one mechanism, the deprotection of alkyl triflates is a new reaction. Studies with 18O labelled DMF indicate that the C-O bond stays intact and hence it is the S-O bond that cleaves, underlining that the cleavage results from the extraordinary electron donor capability of 13. Trifluoromethanesulfonamides are converted to the parent amines in like manner, representing the first cleavage of such substrates by a ground-state organic reducing reagent.