148991-43-9Relevant articles and documents
L-valine-substituted maleimide derivative as well as preparation method and application thereof
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Paragraph 0040; 0046, (2018/11/03)
The invention discloses an L-valine-substituted maleimide derivative as well as a preparation method thereof. The preparation method comprises the following steps: synthesizing 1-aryl-3-methyl-4-formyl-5-(1,2,4-triazolyl)pyrazol; then adopting a method of
D-valine substituted maleimide derivative, and preparation method and application thereof
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Paragraph 0040; 0046, (2018/11/22)
The invention discloses a D-valine substituted maleimide derivative and a preparation method thereof. The preparation method comprises compositing 1-aryl-3-methyl-4-formyl-5-(1,2,4-triazolyl)pyrazol;subjecting the 1-aryl-3-methyl-4-formyl-5-(1,2,4-triazol
Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions
Buller, Fabian,Mannocci, Luca,Zhang, Yixin,Dumelin, Christoph E.,Scheuermann, Joerg,Neri, Dario
supporting information; experimental part, p. 5926 - 5931 (2009/05/31)
DNA-encoded chemical libraries are increasingly being employed for the identification of binding molecules to protein targets of pharmaceutical relevance. Here, we describe the synthesis and characterization of a DNA-encoded chemical library, consisting of 4000 compounds generated by Diels-Alder cycloaddition reactions. The compounds were encoded with unique DNA fragments which were generated through a stepwise assembly process and serve as amplifiable bar codes for the identification and relative quantification of library members.
Synthesis and properties of chiral N,N-maleoyl derivatives and Diels-Alder reactions with cyclopentadiene
Bodtke,Otto, Hans-Hartwig
, p. 803 - 813 (2007/10/03)
Maleyl amino acid derivatives were prepared from maleic anhydride and cyclized by reaction with ZnCl2 and hexamethyldisilazane yielding maleoyl derivatives. These derivatives were used as dienophiles in cycloadditions with cyclopentadiene. The