150098-04-7

Basic information

• Product Name: N-Trityl Losartan Isomer
• Synonyms: Losartan Isomer N2-Trityl Impurity;1H-Imidazole-4-methanol, 2-butyl-5-chloro-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-
• CAS NO: 150098-04-7
• Molecular Formula: C41H37ClN6O
• Molecular Weight: 665.22508
• Mol File: 150098-04-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-Trityl Losartan Isomer(CAS DataBase Reference)
• NIST Chemistry Reference: N-Trityl Losartan Isomer(150098-04-7)
• EPA Substance Registry System: N-Trityl Losartan Isomer(150098-04-7)

Safety Data

• Hazardous Substances Data: 150098-04-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Upstream product

• 79047-41-9 2-n-butyl-4-chloro-5-hydroxymethylimidazole 
• 133051-88-4 N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole 

Relevant articles and documents

Practical Synthesis and Regioselective Alkylation of Methyl 4(5)-(Pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate To Give DuP 532, a Potent Angiotensin II Antagonist

DuP 532 (2), which is a potent angiotensin II receptor antagonist, has been prepared by two different routes.One route, which is more practical for large-scale synthesis, required the preparation of methyl 4(5)-(pentafluoroethyl)-2-propylimidazole-5(4)-carboxylate (9).This imidazole was synthesized in five steps from commercially available 11 in 32percent overall yield.Alternate perfluoroalkylation methods of the iodoimidazole precursor 14 are presented.Imidazole 9 is remarkably stable to basic conditions and is alkylated by 2--4'-(bromomethyl) -1,1'-biphenyl (8), giving only the desired regioisomer.A comparison of the alkylation of the trisubstituted precursors and analogues to 9 with 8 indicate that even under mildly basic conditions (K2CO3/DMF), the mechanism is SE2cB (anionic), except for 2-propyl-4(5)-(hydroxymethyl)imidazole (11) which alkylates as a neutral species (SE2')