152436-04-9

Basic information

• Product Name: FMOC-D-4-METHOXYPHE
• Synonyms: FMOC-ALPHA-ME-D-PHE-OH;FMOC-ALPHA-METHYL-D-PHE;FMOC-ALPHA-METHYL-D-PHENYLALANINE;FMOC-ALPHA-BENZYL-D-ALA;FMOC-4-METHOXY-D-PHE-OH;FMOC-D-TYROSINE(ME)-OH;FMOC-D-TYR(ME)-OH;FMOC-D-PHE(OME)-OH
• CAS NO: 152436-04-9
• Molecular Formula: C25H23NO5
• Molecular Weight: 417.45
• Product Categories: Unusual amino acids;unnatural amino acids;α-Methyl Amino Acids
• Mol File: 152436-04-9.mol

Chemical Properties

• Boiling Point: 621.214 °C at 760 mmHg
• Flash Point: 329.498 °C
• Appearance: White to pale yellow/Powder
• Density: 1.256 g/cm³
• Vapor Pressure: 2.71E-16mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: -15°C
• PKA: 3.81±0.11(Predicted)
• CAS DataBase Reference: FMOC-D-4-METHOXYPHE(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-4-METHOXYPHE(152436-04-9)
• EPA Substance Registry System: FMOC-D-4-METHOXYPHE(152436-04-9)

Safety Data

• Statements: 36/37/38-40-67
• Safety Statements: 23-24/25-36/37
• TSCA: No
• HazardClass: IRRITANT
• Hazardous Substances Data: 152436-04-9(Hazardous Substances Data)

Usage

Uses

Fmoc-alpha-methyl-d-phenylalanine

InChI:InChI=1/C25H23NO4/c1-25(23(27)28,15-17-9-3-2-4-10-17)26-24(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h2-14,22H,15-16H2,1H3,(H,26,29)(H,27,28)/t25-/m1/s1

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 23239-35-2 (S)-2-amino-2-methyl-3-phenylpropanoic acid 
• 1132-26-9 2-methyl-3-phenylalanine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Downstream Products

• 1204418-09-6 α-Me-Phe-Phe-NH2 
• 1204418-11-0 Phe-α-Me-Phe-NH2 
• 1428768-37-9 C₁₉H₃₀N₆O₅ 

Relevant articles and documents

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Nuclear hormone receptor (NR) signaling, currently a therapeutic target in multiple diseases, involves an ordered series of protein interactions to regulate transcription in response to changing hormone levels. Later steps in the process of ligand-dependent signaling are driven by a highly conserved interaction between the NRs and the steroid receptor coactivators (SRCs) that is effected by a conserved interaction motif (L1XXL2L3), known as an NR box. Using computational design and combinatorial chemistry, we have produced novel ∞-helical proteomimetics of the second NR box of SRC2 that exploit structural differences between human estrogen receptor ∞ (hER∞), human estrogen receptor β (hERβ), and human thyroid hormone receptor β (hTRβ). The resulting library sequentially replaced each leucine with non-natural side chains. Screening this library using a quantitative competition assay revealed compounds that selectively inhibit the interaction of SRC2-2 with each individual NR in preference to its interaction with the other NR. This approach generated highly selective compounds from one that had no specificity for a particular family member. These compounds represent the first family-member-selective competitive inhibitors of the protein interactions of transcription factors. Copyright