153364-63-7Relevant articles and documents
Synthesis and characterization of trans-di-(4-pyridyl)porphyrin dimers
Pisano, Simone,Milano, Domenico,Passoni, Nicola,Iengo, Elisabetta,Tecilla, Paolo
, p. 514 - 524 (2016)
Preparation and characterization of a small library of symmetric trans-di(4-pyridyl)porphyrin dimers, obtained by either Glaser-Hay or Sonogashira coupling reactions from appropriately prepared trans-di-4-pyridylporphyrin precursors, is presented. The porphyrin dimers are differentiated by a phenyl-alkynyl bridge of increasing length at one meso-position, while for all the derivatives the two remaining opposite meso-positions are tailored with a phenyl moiety bearing a short polyether chain. Coordination of the four pyridyl groups with appropriate metal fragments may be exploited to construct tubular hollow structures, with varied internal sizes, depending on the choice of the porphyrin dimer component.
Development and characterization of nanoparticles prepared from the mixture of triterpenoids and amphiphilic meso-arylporphirins
Nguen,Zhdanova,Uvarova,Bragina,Mironov,Chupin,Shvets
, p. 161 - 169 (2015)
The mixture of triterpenoids from birch bark and amphiphilic meso-arylprophyrins was used to develop spherical amorphous nanoparticles. The nanoparticles were studied with the methods of electron microscopy, dynamic light scattering, UV spectroscopy, and
Synthesis of asymmetric tetraarylporphyrins and their ytterbium complexes
Rumyantseva,Roshchina,Fedorova,Mironov,Markushev,Shilov
, p. 765 - 774 (2011)
The synthesis of asymmetric meso-aryl-substituted porphyrins containing three 4-methoxycarbonylphenyl groups, and 4-hydroxyphenyl or 4-hydroxy-3-methoxyphenyl radicals or isomeric 3-and 4-pyridyl radicals as a forth substitute, is described. 4-Oxyalkyl derivatives are obtained. The ytterbium complexes of these porphyrins have been synthesized, and their spectral luminescence properties have been studied. A significant difference in the lifetimes of the excited state of ytterbium complexes of the esters and acids of asymmetric porphyrins has been shown. Pleiades Publishing, Ltd., 2011.
Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy
Perumal, Devanathan,Golla, Murali,Pillai, Kavya S.,Raj, Gowtham,Krishna P. K., Anusree,Varghese, Reji
supporting information, p. 2804 - 2810 (2021/04/07)
Targeted photodynamic therapy (PDT) is one of the promising approaches for the selective killing of cancerous cells without affecting the normal cells, and hence designing new strategies for targeted PDT is extremely important. Herein we report the design and synthesis of a new class of nanosheets derived from the self-assembly of the iodo-BODIPY-biotin conjugate as a photosensitizer for targeted PDT applications. The nanosheet exhibits a high extinction coefficient in the NIR region, high singlet oxygen efficiency, no toxicity in the dark and cell targeting ligands (biotin) on the surface, which are necessary features required for an ideal photosensitizer. Overexpression of sodium-dependent multivitamin transporters (SMVTs) in HeLa and A549 (biotin receptor positive cell lines) is explored for the selective uptake of the nanophotosensitizer through receptor mediated endocytosis (interaction between biotin and SMVT). Control experiments using a biotin receptor negative cell line (WI-38) are also carried out to confirm that the specific interaction between the SMVTs and biotin is mainly responsible for the selective uptake of the photosensitizer. Efficient killing of cancerous cells is demonstrated upon light irradiation through the generation of singlet oxygen and other reactive oxygen species around the cellular environment.
A tumor-targeted Photodynamic therapeutic compound
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Paragraph 0016, (2019/10/19)
The present invention relates to a tumor targeting photodynamic therapeutic agent containing a compound represented by chemical formula 1. The compound according to the present invention can significantly improve cancer treatment efficiency.COPYRIGHT KIPO 2019
