154464-24-1 Usage
Uses
Used in Pharmaceutical Industry:
METHYL 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOATE is used as an active ingredient in topical creams, lotions, and ointments for its anti-inflammatory and analgesic properties. It aids in reducing inflammation and pain associated with various conditions, providing relief and comfort to users.
Used in Cosmetic Industry:
In the cosmetic industry, METHYL 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOATE is used as a beneficial ingredient in skincare products. Its anti-inflammatory and analgesic effects contribute to the skincare formulations' efficacy in soothing and alleviating discomfort related to skin conditions.
Used in Organic Synthesis:
METHYL 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOATE also serves as a building block in the synthesis of various organic compounds. It is utilized in the production of other chemicals, expanding its applications beyond topical formulations and into broader chemical manufacturing processes.
Safety and Regulation:
METHYL 3-(CYCLOPENTYLOXY)-4-METHOXYBENZOATE is considered to be a safe and effective ingredient when used in accordance with regulatory guidelines and proper handling procedures. Its widespread use in both pharmaceutical and cosmetic products underscores its established safety profile and beneficial properties.
Check Digit Verification of cas no
The CAS Registry Mumber 154464-24-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,4,6 and 4 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 154464-24:
(8*1)+(7*5)+(6*4)+(5*4)+(4*6)+(3*4)+(2*2)+(1*4)=131
131 % 10 = 1
So 154464-24-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H18O4/c1-16-12-8-7-10(14(15)17-2)9-13(12)18-11-5-3-4-6-11/h7-9,11H,3-6H2,1-2H3
154464-24-1Relevant articles and documents
Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships
Zhou, Zhong-Zhen,Ge, Bing-Chen,Chen, Yu-Fang,Shi, Xiu-Dong,Yang, Xue-Mei,Xu, Jiang-Ping
, p. 7332 - 7339 (2015/11/16)
In this study, a series of catechol-based amides (8a-n) with different amide linkers linking the catecholic moiety to the terminal phenyl ring was designed and synthesized as potent phosphodiesterase (PDE) 4D inhibitors. The inhibitory activities of these compounds were evaluated against the core catalytic domains of human PDE4 (PDE4CAT), full-length PDE4B1 and PDE4D7 enzymes, and other PDE family members. The results indicated the majority of compounds 8a-n displayed moderate to good inhibitory activities against PDE4CAT. Among these compounds, compound 8j with a short amide linker (-CONHCH2-) displayed comparable PDE4CAT inhibitory activity (IC50 = 410 nM) with rolipram. More interestingly, compound 8g, a potent and selective PDE4D inhibitor (IC50 = 94 nM), exhibited a 10-fold selectivity over the PDE4B subtypes and an over 1000-fold selectivity against other PDE family members. Docking simulations suggested that 8g forms three extra H-bonds with the N-H of residue Asn487 and two water molecules.
