6702-50-7

Basic information

• Product Name: Methyl 3-hydroxy-4-methoxybenzoate
• Synonyms: METHYL 3-HYDROXY-4-METHOXYBENZENECARBOXYLATE;METHYL 3-HYDROXY-4-METHOXYBENZOATE;METHYL ISOVANILLATE;RARECHEM AL BF 0068;Methyl 3-hydroxy-4-methoxybenzoate,98%;Methyl 3-hydroxy-4-methoxybenzoateMethyl isovanillate;benzoic acid, 3-hydroxy-4-methoxy-, methyl ester;Methyl 3-hydroxy-4-m
• CAS NO: 6702-50-7
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.17
• Product Categories: Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 6702-50-7.mol
• Article Data: 49

Chemical Properties

• Melting Point: 64-67 °C(lit.)
• Boiling Point: 327.7 °C at 760 mmHg
• Flash Point: 132.8 °C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.000104mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.15±0.10(Predicted)
• CAS DataBase Reference: Methyl 3-hydroxy-4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-hydroxy-4-methoxybenzoate(6702-50-7)
• EPA Substance Registry System: Methyl 3-hydroxy-4-methoxybenzoate(6702-50-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6702-50-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to beige crystalline powder

Uses

Methyl 3-hydroxy-4-methoxybenzoate may be used as starting reagent in the novel synthesis of gefitinib. Synthesis involves the alkylation of starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. It may be used as starting reagent in the synthesis of methyl 5-(benzo[d][1,3]dioxol-5-yl)-4-methoxy-2-nitrobenzoate.

InChI:InChI=1/C9H10O4/c1-12-8-4-3-6(5-7(8)10)9(11)13-2/h3-5,10H,1-2H3

Upstream product

• 67-56-1 methanol 
• 645-08-9 Isovanillic acid 
• 6520-86-1 4-Methoxy-4-acetoxy-3-oxo-3,4-dihydro-benzaldehyd 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 74-88-4 methyl iodide 
• 621-59-0 isovanillin 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 591-51-5 phenyllithium 
• 220884-51-5 methyl 4-acetoxy-4-methoxy-3-oxocyclohexa-1,5-dienecarboxylate 
• 100-58-3 phenylmagnesium bromide 
• 121-98-2 methyl 4-methoxybenzoate 
• 74-83-9 methyl bromide 
• 7664-93-9 sulfuric acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 

Downstream Products

• 57535-57-6 methyl 3-(benzyloxy)-4-methoxy-benzoate 
• 84981-47-5 methyl 3-(n-butoxy)-4-methoxybenzoate 
• 183146-43-2 4-Methoxy-3-oxiranylmethoxy-benzoic acid methyl ester 
• 220884-51-5 methyl 4-acetoxy-4-methoxy-3-oxocyclohexa-1,5-dienecarboxylate 
• 1372627-62-7 methyl 3-((dimethylcarbamothioyl)oxy)-4-methoxybenzoate 
• 97966-31-9 3-ethoxy-4-methoxybenzoic acid methyl ester 
• 215947-98-1 3-[(2-dimethylamino)ethoxy]-4-methoxybenzoic acid 
• 1356154-80-7 methyl 3-(isopentyloxy)-4-methoxybenzoate 

Relevant articles and documents

Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction to Access Thiobenzofurans

A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed, enabling the straightforward and efficient synthesis of various thiobenzofurans in one step. This robust protocol proceeds with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions.

Method for synthesizing 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl-sulfonyl ethylamine

The invention discloses a method for synthesizing 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl-sulfonyl ethylamine and belongs to the technical field of organic synthesis processes. The method comprises the following steps: taking 3-hydroxy-4-methoxybenzoic acid as a raw material, carrying out an esterification reaction to obtain 3-hydroxy-4-methoxybenzoate, reacting with bromoethane to obtain 3-ethyoxyl-4-methoxybenzoate, then reacting with dimethyl sulfone to obtain 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl sulfonyl ethyl ketone, and finally carrying out a reductive amination reaction with ammoniumformate, thereby obtaining the 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl-sulfonyl ethylamine.

NOVEL INHIBITORS OF MAP4K1

The invention relates to novel inhibitors of MAP4K1 (HPK1) useful for the treatment of diseases or disorders characterised by dysregulation of the signal transduction pathways associated with MAPK activation, including hyperproliferative diseases, diseases of immune system dysfunction, inflammatory disorders, neurological diseases, and cardiovascular diseases. The invention further relates to pharmaceutical compositions comprising the same and methods of treatment of said diseases and disorders. The inhibitors are of formula (I) wherein the definitions for A, D, E, F, R5, R6, R7, Z, ring Q, n, x and y are as given in the application.