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157301-82-1

4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 157301-82-1 Structure

  • Basic information

    1. Product Name: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile
    2. Synonyms: 4-Chlor-8-(trifluormethyl)chinolin-3-carbonitril
    3. CAS NO:157301-82-1
    4. Molecular Formula: C11H4ClF3N2
    5. Molecular Weight: 256.61
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 157301-82-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 349.2°C at 760 mmHg
    3. Flash Point: 165°C
    4. Appearance: N/A
    5. Density: 1.5g/cm3
    6. Vapor Pressure: 4.78E-05mmHg at 25°C
    7. Refractive Index: 1.578
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(157301-82-1)
    12. EPA Substance Registry System: 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile(157301-82-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 157301-82-1(Hazardous Substances Data)

157301-82-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 157301-82-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,3,0 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 157301-82:
(8*1)+(7*5)+(6*7)+(5*3)+(4*0)+(3*1)+(2*8)+(1*2)=121
121 % 10 = 1
So 157301-82-1 is a valid CAS Registry Number.

157301-82-1Relevant articles and documents

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood-brain penetration

Hu, Baihua,Bernotas, Ron,Unwalla, Rayomand,Collini, Michael,Quinet, Elaine,Feingold, Irene,Goos-Nilsson, Annika,Wilhelmsson, Anna,Nambi, Ponnal,Evans, Mark,Wrobel, Jay

scheme or table, p. 689 - 693 (2010/06/14)

A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRβ and moderate binding selectivity over LXRα. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding selectivity for LXRβ over LXRα (LXRβ IC50 = 16 nM), good activity for inducing ABCA1 gene expression in a THP macrophage cell line, desired weak potency in the LXRα Gal4 functional assay, and low blood-brain barrier penetration in rat.

Further modification on phenyl acetic acid based quinolines as liver X receptor modulators

Hu, Baihua,Jetter, James,Kaufman, David,Singhaus, Robert,Bernotas, Ronald,Unwalla, Rayomand,Quinet, Elaine,Savio, Dawn,Halpern, Anita,Basso, Michael,Keith, James,Clerin, Valerie,Chen, Liang,Liu, Qiang-Yuan,Feingold, Irene,Huselton, Christine,Azam, Farooq,Goos-Nilsson, Annika,Wilhelmsson, Anna,Nambi, Ponnal,Wrobel, Jay

, p. 3321 - 3333 (2008/02/07)

A series of phenyl acetic acid based quinolines was prepared as LXR modulators. An SAR study in which the C-3 and C-8 positions of the quinoline core were varied led to the identification of two potent LXR agonists 23 and 27. Both compounds displayed good binding affinity for LXRβ and LXRα, and increased expression of ABCA1 in THP-1 cells. These two compounds also had desirable pharmacokinetic profiles in mice and displayed in vivo efficacy in a 12-week Apo E knockout mouse lesion model.

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