854771-69-0

Basic information

• Product Name: 3-Quinolinecarbonitrile, 4-(3-hydroxyphenyl)-8-(trifluoromethyl)-
• CAS NO: 854771-69-0
• Molecular Formula: C17H9F3N2O
• Mol File: 854771-69-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarbonitrile, 4-(3-hydroxyphenyl)-8-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarbonitrile, 4-(3-hydroxyphenyl)-8-(trifluoromethyl)-(854771-69-0)
• EPA Substance Registry System: 3-Quinolinecarbonitrile, 4-(3-hydroxyphenyl)-8-(trifluoromethyl)-(854771-69-0)

Safety Data

• Hazardous Substances Data: 854771-69-0(Hazardous Substances Data)

Upstream product

• 157301-82-1 4-chloro-8-(trifluoromethyl)quinoline-3-carbonitrile 
• 87199-18-6 3-hydroxyphenylboronic acid 

Downstream Products

• 1020735-47-0 4-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)quinoline-3-carbonitrile 

Relevant articles and documents

Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood-brain penetration

A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRβ and moderate binding selectivity over LXRα. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding selectivity for LXRβ over LXRα (LXRβ IC50 = 16 nM), good activity for inducing ABCA1 gene expression in a THP macrophage cell line, desired weak potency in the LXRα Gal4 functional assay, and low blood-brain barrier penetration in rat.