15996-84-6

Basic information

• Product Name: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE
• Synonyms: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE;(RS)-1-[4-(Trifluoromethyl)phenyl]ethylamine 98%;BenzeneMethanaMine, a-Methyl-4-(trifluoroMethyl)-;1-[4-(Trifluoromethyl)phenyl]ethylamine, 4-(1-Aminoethyl)benzotrifluoride;alpha-Methyl-4-(trifluoromethyl)benzylamine 98%;alpha-Methyl-4-(trifluoromethyl)benzylamine98%;1-(4-(trifluoromethyl)phenyl)ethan-1-amine
• CAS NO: 15996-84-6
• Molecular Formula: C₉H₁₀F₃N
• Molecular Weight: 189.18
• Mol File: 15996-84-6.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 76.5-77.5
• Flash Point: 82.9°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.271mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.56±0.10(Predicted)
• CAS DataBase Reference: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(15996-84-6)
• EPA Substance Registry System: (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE(15996-84-6)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• Hazardous Substances Data: 15996-84-6(Hazardous Substances Data)

Usage

General Description

(RS)-1-[4-(trifluoromethyl)phenyl]ethylamine is a chemical compound that belongs to the class of organic compounds known as phenylpropylamines. It is a derivative of phenethylamine and contains a trifluoromethyl substituent at the 4-position of the phenyl ring. (RS)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE has potential applications in various fields such as pharmaceuticals, agrochemicals, and materials science. Its chemical structure and properties make it an important building block for the synthesis of complex organic molecules. Additionally, (RS)-1-[4-(trifluoromethyl)phenyl]ethylamine has the potential for use as a pharmaceutical intermediate in the synthesis of drugs and in the development of new therapeutic agents.

InChI:InChI=1/C9H10F3N/c1-6(13)7-2-4-8(5-3-7)9(10,11)12/h2-6H,13H2,1H3

Upstream product

• 455-18-5 4-CF₃C₆H₄CN 
• 75-16-1 methylmagnesium bromide 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 75-31-0 isopropylamine 
• 852241-17-9 (1R)-2-oxo-1-phenyl-2-({1-[4-(trifluoromethyl)phenyl]ethyl}amino)ethyl Acetate 
• 15996-83-5 (E)-1-(4-(trifluoromethyl)phenyl)ethan-1-one oxime 
• 107496-43-5 1-(4-(trifluoromethyl)phenyl)ethan-1-one O-methyl oxime 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 15996-83-5 1-[4-(trifluoromethyl)phenyl]ethanone oxime 

Downstream Products

• 581812-92-2 (R)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide 
• 581812-91-1 (S)-N-[α-methyl-4-(trifluoromethyl)benzyl] (R)-2-acetoxy-2-phenylethanamide 
• 84499-73-0 (S)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 578027-35-7 (R)-N-[α-ethyl-4-(trifluoromethyl)benzyl]amine 
• 920320-49-6 {1-[1-(4-trifluoromethyl-phenyl)-ethylcarbamoyl]-azetidin-3-yl}-carbamic acid tert-butyl ester 
• 75-31-0 isopropylamine 
• 15996-83-5 (E)-1-(4-(trifluoromethyl)phenyl)ethan-1-one oxime 

Relevant articles and documents

Rh(III)-catalyzed synthesis of isoquinolines using the N-Cl bond of N-chloroimines as an internal oxidant

The Rh(III)-catalyzed coupling of N-chloroimines with alkynes for the efficient synthesis of isoquinolines is reported. This represents the first use of the N-Cl bond of N-chloroimines as an internal oxidant for construction of the isoquinoline skeleton. The synthesis features atom and step economy, a green solvent (EtOH), mild reaction conditions, and a broad substrate scope.

Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2 H-Isoindoles

We report herein the first use of N-chloroimines as effective synthons for directed C-H functionalization. Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates allows for efficient dechlorinative/dephosphonative access to 2H-isoindoles. Further deesterification under Ni(II) catalysis enables the complete elimination of reactivity-assisting groups and full exposure of reactivity of C3 and N2 ring atoms for attaching structurally distinct appendages.

N-Alkylation of Aqueous Ammonia with Alcohols Leading to Primary Amines Catalyzed by Water-Soluble N-Heterocyclic Carbene Complexes of Iridium

A new catalytic system for the N-monoalkylation of aqueous ammonia with a variety of alcohols was developed. Water-soluble dicationic complexes of iridium bearing N-heterocyclic carbene and diammine ligands exhibited high catalytic activity for this type of reaction on the basis of hydrogen-transfer processes without generating harmful or wasteful byproducts. Various primary amines were efficiently synthesized by using safe, inexpensive, and easily handled aqueous ammonia as a nitrogen source. For example, the reaction of 1-(4-methylphenyl)ethanol with aqueous ammonia in the presence of a water-soluble N-heterocyclic carbene complex of iridium at 150 °C for 40 h gave 1-(4-methylphenyl)ethylamine in 83 % yield.