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16052-06-5

EPPS, also known as N-(2-hydroxyethylpiperazin-N'-yl)propanesulfonic acid, is a widely utilized buffering agent in the fields of biology and biochemistry. It is a white crystalline powder that serves as a Good's buffer, which is a group of buffers that are useful for maintaining a stable pH in various biological systems.

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  • High quality [2-hydroxyethyl]piperazine-n’-[3-propancesulfonicacid];4-(2-hydroxyethyl)-1-piperazinepropanesulfonicaci supplier in China

    Cas No: 16052-06-5

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  • 1 Kilogram

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  • Simagchem Corporation
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  • 16052-06-5 Structure

  • Basic information

    1. Product Name: EPPS
    2. Synonyms: HEPPS(EPPS);4-(2-Hydroxyethyl)pi;HEPE;HEPPS 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid;4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid HEPPS/EPPS/HEPE;4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid[HEPPS];4-Hydroxyerhylpiperazine-1-propanesulfonic acid
    3. CAS NO:16052-06-5
    4. Molecular Formula: C9H20N2O4S
    5. Molecular Weight: 252.33
    6. EINECS: 240-198-8
    7. Product Categories: buffer;Pharmaceutical Intermediates;Miscellaneous Biochemicals;Biochemistry;Good's Buffers
    8. Mol File: 16052-06-5.mol

  • Chemical Properties

    1. Melting Point: 237-239 °C(lit.)
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: White/Powder/Solid
    5. Density: 1.2684 (rough estimate)
    6. Refractive Index: 1.6800 (estimate)
    7. Storage Temp.: Store at RT.
    8. Solubility: H2O: 1 M at 20 °C, clear, colorless
    9. PKA: 8.0(at 25℃)
    10. Water Solubility: Soluble in water. 25.2 g/L (20°C)
    11. BRN: 3957385
    12. CAS DataBase Reference: EPPS(CAS DataBase Reference)
    13. NIST Chemistry Reference: EPPS(16052-06-5)
    14. EPA Substance Registry System: EPPS(16052-06-5)

  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38-22
    3. Safety Statements: 24/25-36-26
    4. WGK Germany: 3
    5. RTECS: TM2649130
    6. TSCA: Yes
    7. HazardClass: IRRITANT
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 16052-06-5(Hazardous Substances Data)

16052-06-5 Usage

Uses

Used in Biology and Biochemistry:
EPPS is used as a buffering agent for maintaining a stable pH in biological and biochemical applications. Its ability to resist changes in pH makes it a valuable component in various experiments and procedures.
Used in Ultrathin Isoelectric Focusing Gels:
In the field of proteomics, EPPS is employed as a separator in ultrathin isoelectric focusing gels. It enhances the resolution of phosphoglucomutase, a crucial enzyme involved in the regulation of glucose metabolism, by improving the separation of proteins during isoelectric focusing.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 16052-06-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,0,5 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16052-06:
(7*1)+(6*6)+(5*0)+(4*5)+(3*2)+(2*0)+(1*6)=75
75 % 10 = 5
So 16052-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

16052-06-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
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  • TCI America

  • (H0576)  4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component for biological research]  >98.0%(T)

  • 16052-06-5

  • 25g

  • 650.00CNY

  • Detail

  • Alfa Aesar

  • (A13714)  EPPS, 99%   

  • 16052-06-5

  • 25g

  • 276.0CNY

  • Detail

  • Alfa Aesar

  • (A13714)  EPPS, 99%   

  • 16052-06-5

  • 100g

  • 833.0CNY

  • Detail

16052-06-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name HEPPS

1.2 Other means of identification

Product number -
Other names Hepps

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16052-06-5 SDS

16052-06-5Synthetic route

copper hydroxide
20427-59-2

copper hydroxide

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

N-(2-hydroxyethyl)-piperazine-N'-3-propane sulfonic acid copper(II) salt

N-(2-hydroxyethyl)-piperazine-N'-3-propane sulfonic acid copper(II) salt

Conditions
ConditionsYield
metal hydroxide dissoln. in org. acid soln. (pH 7 adjusting with additional org. acid); repeated dialysis against Cu(II)-salt soln., then against pure water;
cadmium(II) hydroxide

cadmium(II) hydroxide

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

N-(2-hydroxyethyl)-piperazine-N'-3-propane sulfonic acid cadmium(II) salt

N-(2-hydroxyethyl)-piperazine-N'-3-propane sulfonic acid cadmium(II) salt

Conditions
ConditionsYield
metal hydroxide dissoln. in org. acid soln. (pH 7 adjusting with additional org. acid); repeated dialysis against Cd-salt soln., then against pure water;
4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

tetra-n-butylphosphonium hydroxide
14518-69-5

tetra-n-butylphosphonium hydroxide

[TBP][EPPS]

[TBP][EPPS]

Conditions
ConditionsYield
In water at 20℃;
tetramethyl ammoniumhydroxide
75-59-2

tetramethyl ammoniumhydroxide

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

C9H19N2O4S(1-)*C4H12N(1+)

C9H19N2O4S(1-)*C4H12N(1+)

Conditions
ConditionsYield
In water at 20℃; for 12h;
tetraethylammonium hydroxide
77-98-5

tetraethylammonium hydroxide

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

C9H19N2O4S(1-)*C8H20N(1+)

C9H19N2O4S(1-)*C8H20N(1+)

Conditions
ConditionsYield
In water at 20℃; for 12h;
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid
16052-06-5

4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid

C9H19N2O4S(1-)*C16H36N(1+)

C9H19N2O4S(1-)*C16H36N(1+)

Conditions
ConditionsYield
In water at 20℃; for 12h;

16052-06-5Upstream product

16052-06-5Downstream Products

16052-06-5Relevant articles and documents

METHODS AND COMPOSITIONS FOR RAPIDLY DECREASING EPIGENETIC AGE AND RESTORATION OF MORE YOUTHFUL FUNCTION

-

, (2020/03/01)

Disclosed are methods and compositions of reducing the epigenetic age of mammalian organism, especially an adult human of geriatric age. The methods provide for the proliferation of endogenous stem cells using mitochondrial fusion and a UCP2 blocker or other stimulants; supplying stem cells with nutrition to prevent cell cycle arrest; and removal of senescent somatic cells using senolytic treatments. The proliferation of endogenous neural stem cells after plaque removal for the treatment of Alzheimer's is also disclosed.

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