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4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1620-79-7 Structure
  • Basic information

    1. Product Name: 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE
    2. Synonyms: 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE;4-Methyl-2-trifluormethyl-pyridin
    3. CAS NO:1620-79-7
    4. Molecular Formula: C7H6F3N
    5. Molecular Weight: 161.12
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1620-79-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 171℃
    3. Flash Point: 40.6°C
    4. Appearance: /
    5. Density: 1.216g/cm3
    6. Vapor Pressure: 6.66mmHg at 25°C
    7. Refractive Index: 1.438 (589.3 nm 25℃)
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. PKA: 1.22±0.20(Predicted)
    11. CAS DataBase Reference: 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE(1620-79-7)
    13. EPA Substance Registry System: 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE(1620-79-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1620-79-7(Hazardous Substances Data)

1620-79-7 Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 765, 1958 DOI: 10.1021/jo01099a618

Check Digit Verification of cas no

The CAS Registry Mumber 1620-79-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,2 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1620-79:
(6*1)+(5*6)+(4*2)+(3*0)+(2*7)+(1*9)=67
67 % 10 = 7
So 1620-79-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6F3N/c1-5-2-3-11-6(4-5)7(8,9)10/h2-4H,1H3

1620-79-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-METHYL-2-(TRIFLUOROMETHYL)PYRIDINE

1.2 Other means of identification

Product number -
Other names 4-Methyl-2-trifluormethyl-pyridin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1620-79-7 SDS

1620-79-7Downstream Products

1620-79-7Relevant articles and documents

Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source

Kariofillis, Stavros K.,Shields, Benjamin J.,Tekle-Smith, Makeda A.,Zacuto, Michael J.,Doyle, Abigail G.

supporting information, p. 7683 - 7689 (2020/04/22)

Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

Deoxofluorination of (Hetero)aromatic Acids

Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.

, p. 3110 - 3124 (2020/03/23)

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Trifluoromethylation process for bromo-pyridine and derivatives thereof

-

Paragraph 0054-0056, (2018/07/30)

The invention belongs to the field of organic chemistry and relates to a trifluoromethylation process for bromo-pyridine and derivatives thereof. The process disclosed by the invention comprises the following steps: by taking a bromo-pyridine compound with a formula a structure as a raw material, performing trifluoromethylation under the action of a Maben reagent fluoro-S-( trifluoromethyl)-dibenzothiophene salt having a formula c structure, thereby obtaining the tirfluoromethylpyridine compound with a formula b structure. The structural formula is as shown in the specification. In the formula, X- is Bronst conjugate base, R is H or -CN or halogen or C1-C6 alkyl or C1-C6 alkoxy or -OH or -R1OH or COR2 or -CO2R3 or -CONR4 or -NR5R6; R1 is C1-C6 akyl; R2, R3 and R4 are identically or differently H or C1-C6 alkyl; and the R5 and R6 are identically or differently H or O or C1-C6 alkyl or C1-C6 alkoxy.

Trifluoromethylation of aryl and heteroaryl halides with fluoroform-derived CuCF3: Scope, limitations, and mechanistic features

Lishchynskyi, Anton,Novikov, Maxim A.,Martin, Eddy,Escudero-Adan, Eduardo C.,Novak, Petr,Grushin, Vladimir V.

, p. 11126 - 11146 (2013/12/04)

Fluoroform-derived CuCF3 recently discovered in our group exhibits remarkably high reactivity toward aryl and heteroaryl halides, performing best in the absence of extra ligands. A broad variety of iodoarenes undergo smooth trifluoromethylation with the ligandless CuCF3 at 23-50 C to give the corresponding benzotrifluorides in nearly quantitative yield. A number of much less reactive aromatic bromides also have been trifluoromethylated, including pyridine, pyrimidine, pyrazine, and thiazole derivatives as well as aryl bromides bearing electron-withdrawing groups and/or ortho substituents. Only the most electrophilic chloroarenes can be trifluoromethylated, e.g., 2-chloronicotinic acid. Exceptionally high chemoselectivity of the reactions (no side-formation of arenes, biaryls, and C2F5 derivatives) has allowed for the isolation of a large number of trifluoromethylated products in high yield on a gram scale (up to 20 mmol). The CuCF3 reagent is destabilized by CuX coproduced in the reaction, the magnitude of the effect paralleling the Lewis acidity of CuX: CuCl > CuBr > CuI. While SNAr and SRN1 mechanisms are not operational, there is a well-pronounced ortho effect, i.e., the enhanced reactivity of ortho-substituted aryl halides 2-RC6H4X toward CuCF3. Intriguingly, this ortho-effect is observed for R = NO2, COOH, CHO, COOEt, COCH3, OCH3, and even CH3, but not for R = CN. The fluoroform-derived CuCF3 reagent and its reactions with haloarenes provide an unmatched combination of reactivity, selectivity, and low cost.

Hetero-Diels-Alder reactions of N-phosphoryltrihaloacetimidoyl chlorides with 1,3-butadienes

Kolotylo, Mykola V.,Synytsya, Oleksii A.,Onys'ko, Petro P.

, p. 118 - 126 (2013/09/24)

Hetero-Diels-Alder reactions of N-phosphoryltrihaloacetimidoyl chlorides with 1,3-butadienes led to new 2-chloro-2-trihalomethyl substituted tetrahydropyridine adducts. Cycloadducts with CF3 group undergo thermal or acid catalyzed dehydrochlori

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