16295-38-8

Basic information

• Product Name: Z-GLY-LEU-GLY-OH
• Synonyms: Z-GLY-LEU-GLY-OH
• CAS NO: 16295-38-8
• Molecular Formula: C₁₈H₂₅N₃O₆
• Molecular Weight: 379.41
• Mol File: 16295-38-8.mol

Chemical Properties

• Melting Point: 142-144 °C
• Boiling Point: 711.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.236±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.34±0.10(Predicted)
• CAS DataBase Reference: Z-GLY-LEU-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLY-LEU-GLY-OH(16295-38-8)
• EPA Substance Registry System: Z-GLY-LEU-GLY-OH(16295-38-8)

Safety Data

• Hazardous Substances Data: 16295-38-8(Hazardous Substances Data)

Upstream product

• 2766-19-0 Z-Gly-Leu-Gly-OEt 
• 121475-42-1 N-(N-benzyloxycarbonyl-glycyl)-L-thioleucine S-phenyl ester 
• 56-40-6 glycine 
• 4865-56-9 N-benzyloxycarbonyl-thioglycine S-(4-nitro-phenyl ester) 
• 1421-69-8 (S)-2-(2-Benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoic acid 
• 1738-86-9 Z-Gly-ONp 
• 2899-56-1 N-benzyloxycarbonylglycine cyanomethylester 
• 7352-21-8 Cbz-glycylleucine ethyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 61-90-5 L-leucine 

Downstream Products

• 122411-91-0 N-[N-(N-benzyloxycarbonyl-glycyl)-L-leucyl]-thioglycine S-(4-nitro-phenyl ester) 
• 120335-34-4 N-benzyloxycarbonyl-glycyl=>L-leucyl=>glycyl=>glycyl=>L-leucyl=>-thioglycine S-(4-nitro-phenyl ester) 
• 16421-97-9 N-benzyloxycarbonyl-glycyl=>L-leucyl=>glycyl=>glycyl=>L-leucyl=>-glycine ethyl ester 
• 112274-13-2 N-benzyloxycarbonyl-glycyl=>L-leucyl=>glycyl=>L-leucyl=>-glycine 

Relevant articles and documents

Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation

Several series of dipeptides and tripeptides were prepared via an activation-coupling method involving the in situ formation of a p-nitrophenyl ester of an (N-protected) amino acid, followed by coupling with an unprotected amino acid in partially aqueous solutions. The resulting peptide is easily isolated by precipitation. In general, the yields obtained are good to excellent and racemization is minimal. This method is particularly advantageous with respect to its simplicity and lack of obligatory side chain protection/deprotection steps.

INVESTIGATION ON COUPLING PEPTIDES TO AMINOMETHYL POLYMERS

Different peptide bond forming methods for attachment of model peptides to aminomethyl polymers have been compared.It has been observed that the yield of reaction depends on such features of polymer as quantity of functional groups and degree of its cross-linking.The sequential Edman degradation of a model peptide corresponding to 5 to 9 fragment of substance P was performed by the solid-phase technique.