16564-43-5 Usage
Chemical Properties
White to off-white powder
Uses
Different sources of media describe the Uses of 16564-43-5 differently. You can refer to the following data:
1. Glycochenodeoxycholic Acid Sodium Salt is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
2. Sodium glycochenodeoxycholate has been used in a study to assess the repair of DNA damage induced by bile salts. It has also been used in a study to investigate enterotoxin production by Clostridium perfringens type A in the presence of human bile salts.
Definition
ChEBI: A bile acid salt that is the sodium salt of glycochenodeoxycholic acid.
Purification Methods
Dissolve it in EtOH, filter it and concentrate it to crystallisation, and recrystallise from a little EtOH. It also recrystallises from EtOH/Et2O. [Beilstein 10 IV 1611.]
Check Digit Verification of cas no
The CAS Registry Mumber 16564-43-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,5,6 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 16564-43:
(7*1)+(6*6)+(5*5)+(4*6)+(3*4)+(2*4)+(1*3)=115
115 % 10 = 5
So 16564-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H43NO5.Na/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;/m1./s1
16564-43-5Relevant articles and documents
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts
Venturoni, Francesco,Gioiello, Antimo,Sardella, Roccaldo,Natalini, Benedetto,Pellicciari, Roberto
experimental part, p. 4109 - 4115 (2012/06/15)
A multi-gram scale protocol for the N-acyl amidation of bile acids with glycine and taurine has been successfully developed under continuous flow processing conditions. Selecting ursodeoxycholic acid (UDCA) as the model compound and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) as the condensing agent, a modular mesoreactor assisted flow set-up was employed to significantly speed up the optimization of the reaction conditions and the flow scale-up synthesis. The results in terms of yield, in line purification, analysis, and implemented flow set-up for the reaction optimization and large scale production are reported and discussed.