1692-78-0

Basic information

• Product Name: 1-phenyl-4-trifluoroacetyl-piperazine
• Synonyms: 1-phenyl-4-trifluoroacetyl-piperazine
• CAS NO: 1692-78-0
• Molecular Weight: 258.243
• Mol File: 1692-78-0.mol

Chemical Properties

• CAS DataBase Reference: 1-phenyl-4-trifluoroacetyl-piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-4-trifluoroacetyl-piperazine(1692-78-0)
• EPA Substance Registry System: 1-phenyl-4-trifluoroacetyl-piperazine(1692-78-0)

Safety Data

• Hazardous Substances Data: 1692-78-0(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 407-25-0 trifluoroacetic anhydride 
• 111185-41-2 1-(2,5-dihydro-1H-pyrrol-1-yl)-2,2,2-trifluoroethanone 
• 62-53-3 aniline 

Downstream Products

• 123643-31-2 1-[4-(4-nitro-phenylazo)-phenyl]-piperazine 
• 122648-77-5 2-Cyano-3-<4-<4-(trifluoroacetyl)piperazinyl>phenyl>propenoic acid 
• 122648-78-6 2-Cyano-3-(4-piperazinylphenyl)propenoic acid 
• 92-54-6 4-phenyl-1-piperazine 
• 122648-76-4 4-<4-(Trifluoroacetyl)piperazinyl>benzaldehyde 

Relevant articles and documents

Heterocyclic derivatives as modulators of ion channels

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Head-to-Tail Assemblies of Dipolar, Piperazine-Linked Chromophores: Synthesis, X-ray Structure, and Dielectric Characterization

A dimer and a mixture of oligomers of acceptor-substituted anilines were prepared, either by Knoevenagel condensation of substituted cyanoacetylpiperazines with p-aminobenzaldehydes or by carbonyldiimidazole-promoted coupling of phenylpiperazines with p-a

Synthesis of Piperazines and Thiomorpholines by Ozonolysis of Cyclic Olefins and Reductive N-Alkylation

Ozonized 1-trifluoroacetyl-3-pyrroline (2a) and 3-sulfolene (6) were reduced with sodium cyanoborohydride (1) to afford the dialdehyde, which reacted in situ with the primary amines 3ad in the presence of 1 to give the piperazines 4ad (2160 percent) and the dioxothiomorpholines 7ad (2676 percent).Reduction of 7a and 7c with diisobutylaluminum hydride yielded the thiomorpholines 8a and 8c, respectively.On the other hand, the 9-membered azacrown ethers 10 and 11 were obtained when N,N'-dibenzylethylenediamine (9) was employed.The dioxothiomorpholine derivatives 13 of amino acids were also prepared by the same treatment.