169610-52-0Relevant articles and documents
MLKL INHIBITORS
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Paragraph 0368-0369, (2018/09/26)
Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated disorder is pathology associated necroptosis, including ischemia-reperfusion damage, neurodegeneration, and inflammatory diseases such as acute pancreatitis, multiple sclerosis, inflammatory bowel disease, and allergic colitis.
Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety
Feng, Lianshun,Lv, Kai,Liu, Mingliang,Wang, Shuo,Zhao, Jing,You, Xuefu,Li, Sujie,Cao, Jue,Guo, Huiyuan
, p. 125 - 136 (2012/11/07)
A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: 90: 1 μg/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 μg/mL). Crown Copyright
Effect of methoxy substituents on the excited state properties of stilbene
Shinohara, Yoshihiro,Arai, Tatsuo
experimental part, p. 1500 - 1504 (2009/05/06)
Excited state properties of stilbenes having methoxy substituents at the ortho position of the phenyl ring have been studied and the remarkable methoxy substituent effect to suppress the fluorescence quantum yield depending on the number of methoxy substi
Differential cleavage of arylmethyl ethers: Reactivity of 2,6-dimethoxybenzyl ethers
Falck,Barma,Baati, Rachid,Mioskowski, Charles
, p. 1281 - 1283 (2007/10/03)
CrCl2/LiI selectively cleave benzyl ethers and methoxy-substituted benzyl ethers (see scheme) in the order: C6H5CH2OR 6H4CH2OR 2C6H3CH2OR 2C6H3CH2OR. In contrast, C6H5CH2OR is more readily cleaved than 2,6-(MeO)2C6H3CH2OR during catalytic hydrogenolysis while 3,4-(MeO)2C6H3CH2OR is cleaved faster than 2,6-(MeO)2C6H3CH2OR with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).
Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
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, (2008/06/13)
Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: STR1 in which U is selected from --(CH2)n -- and ethylidene; Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is STR2 in which V is selected from hydrogen, halogen, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsilyloxy, dialkylamino, cyano, nitro, hydroxy, and phenyl; Y and Z are independently selected from hydrogen and alkoxy; W and X taken together is --OCH2 CH2 O--, --CH2 C(CH3)2 O--, --OC(CH3)2 O--, or --N=C(C2 H5)O--; R1 and R2 are independently selected from phenyl substituted with halogen, alkyl, haloalkyl, haloalkoxy, alkoxyalkyl, hydroxy, arylthio, alkoxy, dialkylamino, dialkylaminosulfonyl, hydroxyalkylaminocarbonyl, alkylsulfonyloxy, and haloalkylsulfonyloxy; and n is 1, 2, or 3.
Insecticidal n-(substituted arylmethyl)-4-[bis(substituted phenyl) methyl]pi
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, (2008/06/13)
Compounds of the following structure, the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides: STR1 in which U is selected from STR2 Q is selected from hydrogen, hydroxy, sulfhydryl, and fluorine; R is selected from a heterocycle having 5 or 6 ring atoms, optionally fused to a benzene ring, and STR3 wherein V, W, X, Y, Z are as defined in the specification.