1722-11-8

Basic information

• Product Name: 1-(6-Chloro-pyridazino-3-yl)piperidine
• Synonyms: 3-CHLORO-6-PIPERIDIN-1-YL-PYRIDAZINE;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;1-(6-CHLORO-PYRIDAZINO-3-YL)PIPERIDINE;3-Chloro-6-piperidinopyridazine;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;3-chloro-6-(1-piperidyl)pyridazine;Pyridazine, 3-chloro-6-(1-piperidinyl)-
• CAS NO: 1722-11-8
• Molecular Formula: C₉H₁₂ClN₃
• Molecular Weight: 197.66
• EINECS: 200-001-2
• Mol File: 1722-11-8.mol

Chemical Properties

• Melting Point: 80～82℃
• Boiling Point: 388.6 °C at 760 mmHg
• Flash Point: 188.8 °C
• Appearance: /
• Density: 1.234 g/cm³
• Vapor Pressure: 3.02E-06mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.62±0.10(Predicted)
• CAS DataBase Reference: 1-(6-Chloro-pyridazino-3-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Chloro-pyridazino-3-yl)piperidine(1722-11-8)
• EPA Substance Registry System: 1-(6-Chloro-pyridazino-3-yl)piperidine(1722-11-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1722-11-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1-(6-Chloro-pyridazino-3-yl)piperidine is utilized as a key intermediate in the synthesis of various pharmaceutical drugs. Its specific chemical properties allow it to be a building block for the creation of new molecules with therapeutic potential.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(6-Chloro-pyridazino-3-yl)piperidine serves as a valuable compound for research purposes. It is employed in the exploration of new chemical entities and the study of their interactions with biological targets, which can lead to the discovery of novel therapeutic agents.
Used in Drug Design and Optimization:
1-(6-Chloro-pyridazino-3-yl)piperidine is used as a structural element in drug design, where its unique features can be leveraged to optimize the pharmacokinetic and pharmacodynamic properties of new drug candidates. This can enhance the efficacy, selectivity, and safety profiles of the resulting medications.
Used in Chemical Synthesis:
1-(6-Chloro-pyridazino-3-yl)piperidine is also used in chemical synthesis processes outside the realm of pharmaceuticals, where its reactivity and structural attributes can be harnessed to produce a variety of other chemical products with different applications.
Overall, the applications of 1-(6-Chloro-pyridazino-3-yl)piperidine are broad and multidisciplinary, reflecting its versatility and the ongoing interest in exploring its potential in various scientific and industrial contexts.

InChI:InChI=1/C9H12ClN3/c10-8-4-5-9(12-11-8)13-6-2-1-3-7-13/h4-5H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 141-30-0 3,6-dichlorpyridazine 

Downstream Products

• 77778-14-4 3-phenylethynyl-6-piperidinopyridazine 
• 1201653-07-7 1-{3-[7-(6-piperidin-1-yl-pyridazin-3-yl)-imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea 
• 68206-18-8 3-phenyl-6-(piperidin-1-yl)pyridazine 

Relevant articles and documents

Synthesis and Biological Evaluation of 2-substituted-6-(morpholinyl/piperidinyl)pyridazin-3(2H)-ones as Potent and Safer Anti-inflammatory and Analgesic Agents

A series of 2-substituted-6-(morpholinyl/piperidinyl)pyridazin-3(2H)-ones was synthesized and the structures were established using various spectroscopic techniques. The target compounds were screened for anti-inflammatory and analgesic activities at 20 and 40?mg/kg. The safety of the synthesized derivatives was evaluated by assessing anti-platelet activity and ulcer index. The obtained pharmacological data revealed that 6-morpholinyl derivatives 4a–12a were found to be somewhat more potent than 6-piperidinyl derivatives 4b–6b. The 6-morpholinyl substituted pyridazinone 12a exhibited maximum anti-inflammatory and analgesic activities. Homoveratrylamine substituted compounds 6a and 6b emerged as promising leads in both the series with good anti-inflammatory and analgesic activities without any ulcerogenicity. Anti-platelet activity results of the compounds of both the series showed significantly low bleeding time in comparison with standard drug aspirin indicating the cardiovascular safety of new pyridazinones.

Selective mono-amination of dichlorodiazines

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs

Alpha7 nicotinic acetylcholine receptors (nAChRs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associated with schizophrenia and Alzheimer's disease (AD). Structure affinity relationship studies of the previously described α7 agonist SEN12333 (8), have resulted in the identification of compound 45, a potent and selective agonist of the α7 nAChR with enhanced affinity and improved physicochemical properties over the parent compound (SEN12333, 8).

An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines

3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.