1722-11-8

Basic information

• Product Name: 1-(6-Chloro-pyridazino-3-yl)piperidine
• Synonyms: 3-CHLORO-6-PIPERIDIN-1-YL-PYRIDAZINE;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;1-(6-CHLORO-PYRIDAZINO-3-YL)PIPERIDINE;3-Chloro-6-piperidinopyridazine;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;3-chloro-6-(1-piperidyl)pyridazine;Pyridazine, 3-chloro-6-(1-piperidinyl)-
• CAS NO: 1722-11-8
• Molecular Formula: C₉H₁₂ClN₃
• Molecular Weight: 197.66
• EINECS: 200-001-2
• Mol File: 1722-11-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 80～82℃
• Boiling Point: 388.6 °C at 760 mmHg
• Flash Point: 188.8 °C
• Appearance: /
• Density: 1.234 g/cm³
• Vapor Pressure: 3.02E-06mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.62±0.10(Predicted)
• CAS DataBase Reference: 1-(6-Chloro-pyridazino-3-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Chloro-pyridazino-3-yl)piperidine(1722-11-8)
• EPA Substance Registry System: 1-(6-Chloro-pyridazino-3-yl)piperidine(1722-11-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1722-11-8(Hazardous Substances Data)

Usage

General Description

1-(6-Chloro-pyridazino-3-yl)piperidine is a chemical compound with the molecular formula C11H14ClN3. It is a piperidine derivative that contains a 6-chloro-pyridazino-3-yl group. 1-(6-Chloro-pyridazino-3-yl)piperidine has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceutical drugs. The specific properties and uses of 1-(6-Chloro-pyridazino-3-yl)piperidine can vary depending on the research and development context in which it is being utilized. Overall, its unique chemical structure and potential pharmacological activities make it an interesting target for further study and exploration in various scientific and industrial applications.

InChI:InChI=1/C9H12ClN3/c10-8-4-5-9(12-11-8)13-6-2-1-3-7-13/h4-5H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 141-30-0 3,6-dichlorpyridazine 

Downstream Products

• 68206-18-8 3-phenyl-6-(piperidin-1-yl)pyridazine 
• 1201653-07-7 1-{3-[7-(6-piperidin-1-yl-pyridazin-3-yl)-imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea 
• 77778-14-4 3-phenylethynyl-6-piperidinopyridazine 

Relevant articles and documents

Synthesis and Biological Evaluation of 2-substituted-6-(morpholinyl/piperidinyl)pyridazin-3(2H)-ones as Potent and Safer Anti-inflammatory and Analgesic Agents

A series of 2-substituted-6-(morpholinyl/piperidinyl)pyridazin-3(2H)-ones was synthesized and the structures were established using various spectroscopic techniques. The target compounds were screened for anti-inflammatory and analgesic activities at 20 and 40?mg/kg. The safety of the synthesized derivatives was evaluated by assessing anti-platelet activity and ulcer index. The obtained pharmacological data revealed that 6-morpholinyl derivatives 4a–12a were found to be somewhat more potent than 6-piperidinyl derivatives 4b–6b. The 6-morpholinyl substituted pyridazinone 12a exhibited maximum anti-inflammatory and analgesic activities. Homoveratrylamine substituted compounds 6a and 6b emerged as promising leads in both the series with good anti-inflammatory and analgesic activities without any ulcerogenicity. Anti-platelet activity results of the compounds of both the series showed significantly low bleeding time in comparison with standard drug aspirin indicating the cardiovascular safety of new pyridazinones.

Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs

Alpha7 nicotinic acetylcholine receptors (nAChRs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associated with schizophrenia and Alzheimer's disease (AD). Structure affinity relationship studies of the previously described α7 agonist SEN12333 (8), have resulted in the identification of compound 45, a potent and selective agonist of the α7 nAChR with enhanced affinity and improved physicochemical properties over the parent compound (SEN12333, 8).