17238-66-3

Basic information

• Product Name: 4-MORPHOLINECARBOXAMIDINE
• Synonyms: 4-MORPHOLINECARBOXAMIDINE;morpholine-4-carboxamidine;Morpholin-4-carboximidamide;4-Morpholinecarboximidamide;morpholine-4-carboximidamide sulfate;Morpholino-4-carboxaMidine
• CAS NO: 17238-66-3
• Molecular Formula: C₅H₁₁N₃O
• Molecular Weight: 129.16
• EINECS: 604-604-1
• Product Categories: pharmacetical
• Mol File: 17238-66-3.mol

Chemical Properties

• Boiling Point: 222.624 °C at 760 mmHg
• Flash Point: 88.44 °C
• Appearance: /
• Density: 1.358 g/cm³
• Storage Temp.: 2-8°C
• PKA: 12.19±0.20(Predicted)
• CAS DataBase Reference: 4-MORPHOLINECARBOXAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINECARBOXAMIDINE(17238-66-3)
• EPA Substance Registry System: 4-MORPHOLINECARBOXAMIDINE(17238-66-3)

Safety Data

• Hazardous Substances Data: 17238-66-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-Morpholinecarboxamidine is used as a reagent in organic synthesis for its ability to facilitate the formation of complex organic molecules, contributing to the development of new pharmaceuticals and other chemical products.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-Morpholinecarboxamidine is utilized as a key component in the development of new drugs, given its potential to interact with biological targets and exhibit therapeutic effects.
Used in Antiviral Applications:
4-Morpholinecarboxamidine is studied as an antiviral agent for its potential to inhibit viral replication and infectivity, offering a new avenue for treating viral diseases.
Used in Anticancer Applications:
4-MORPHOLINECARBOXAMIDINE is being investigated for its anticancer properties, as it may have the ability to target and inhibit the growth of cancer cells, providing a potential therapeutic option for cancer treatment.
Used as an Enzyme Inhibitor:
4-Morpholinecarboxamidine has been studied for its potential as an enzyme inhibitor, which could be beneficial in treating various diseases by modulating enzyme activity.
Used in Diabetes and Metabolic Disorder Treatment:
4-MORPHOLINECARBOXAMIDINE is also being explored for its potential use in the treatment of diabetes and other metabolic disorders, suggesting it may have an impact on glucose metabolism or insulin sensitivity.
These applications highlight the diverse and promising potential of 4-Morpholinecarboxamidine, with ongoing research continuing to uncover its full range of capabilities and therapeutic potential.

InChI:InChI=1/C5H11N3O/c6-5(7)8-1-3-9-4-2-8/h1-4H2,(H3,6,7)/p+1

Upstream product

• 110-91-8 morpholine 
• 625-57-0 O-ethyl thiocarbamate 
• 38184-47-3 3,5-dimethyl-1-pyrazolylformaminidium nitrate 
• 420-04-2 CYANAMID 
• 867-44-7 S-Methylisothiourea sulfate 
• 2986-19-8 carbamimidothioic acid methyl ester 
• 5638-78-8 morpholinoformamidine hydrochloride 

Downstream Products

• 1338250-36-4 C₂₉H₂₅N₇O 
• 1338250-37-5 C₃₀H₂₇N₇O 
• 1338250-38-6 C₂₉H₂₄FN₇O 
• 1338250-39-7 C₂₉H₂₄ClN₇O 
• 1169877-81-9 N-(4-nitrophenyl)morpholine-4-carboxamidine 
• 1169877-82-0 4-[(morpholine-4-carboximidoyl)amino]benzoic acid methyl ester 
• 1169877-83-1 N-(4-cyanophenyl)morpholine-4-carboxamidine 

Relevant articles and documents

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Direct guanylation of amino groups by cyanamide in water: Catalytic generation and activation of unsubstituted carbodiimide by scandium(iii) triflate

Guanylation proceeded efficiently upon treatment of the various amines with cyanamide in the presence of catalytic amounts of scandium(III) triflate under mild conditions. The method did not require the guanylation reagents to be preactivated, and the reaction proceeded efficiently in water. The method, therefore, has practical utility for substrates that dissolve only in aqueous solutions, for example, peptides or pharmacologically important compounds. Georg Thieme Verlag Stuttgart New York.

Synthesis and antitumor activities of a new series of 4,5-dihydro-1H- thiochromeno[4,3-d]pyrimidine derivatives

A new series of 4,5-dihydro-1H-thiochromeno[4,3-d ]pyrimidine derivatives have been designed and synthesized. The antitumor activities of the target compounds have been evaluated in vitro against two human cancer cell lines including A549 (human alveolar adenocarcinoma cell) and H460 (human lung cancer) by MTT assay. Most of the target compounds exhibited significant antitumor activities against A549 and H460 cancer cell lines. The most potent compound 4-(benzo[d][1,3]dioxol-5-yl)-8,9-difluoro-2-(4-methylpiperazin-1-yl)-4, 5-dihydro-1H-thiochromeno[4,3-d]pyrimidine (CH05) (IC50 = 0.44 μM, 3.07 μM) was 2.0 and 8.4 times more active than gefitinib (IC50 = 0.89 μM, 16.81 μM) against A549 and H460 cell lines, respectively.

Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c] quinoline derivatives

A series of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, s

Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine

A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H- pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined. Georg Thieme Verlag Stuttgart.

Optimisation of the synthesis of guanidines from amines via nitroguanidines using 3,5-dimethyl-N-nitro-1H-pyrazole-1-carboxamidine

The synthesis of the useful reagent for the preparation of guanidines, 3,5-dimethyl-N-nitro-1-pyrazole-1-carboxamidine (DMNPC), has been optimised. A detailed protocol for using this reagent for the preparation in pure form of a range of guanidines via nitroguanidines is described. A comparison has been made regarding efficiency between DMNPC and the guanidinylating reagents N,N′-bis-Boc-1-pyrazole-1-carboxamidine (2) and N,N′-bis-Boc- N′-triflylguanidine (3).

A new reagent and its polymer-supported variant for the amidination of amines

New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.

Method of modifying wrinkles using guanidine derivatives

The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1): wherein is a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine or morpholine, and R1and R2are the same or different from each other and independently a hydrogen atom, or an alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino group, or a salt thereof. The cosmetic compositions are excellent in the effects of suppressing wrinkling and of removing wrinkles and give users a pleasant feeling upon use.

Fluorophenoxyphenoxypropionates and derivatives thereof

Novel fluorophenoxyphenoxypropionates and derivatives thereof possess herbicidal activity selectively in the presence of broadleaf crops. Preemergent and postemergent applications are contemplated.

Fluorophenoxyphenoxypropionates and derivatives thereof

Novel intermediates useful in the preparation of fluorophenoxyphenoxypropionates and derivatives thereof which possess herbicidal activity selectively in the presence of broadleaf crops.