17282-04-1

Basic information

• Product Name: 2-Chloro-3-fluoropyridine
• Synonyms: 2-chloro-3-fluoro picoline;2-CHLORO-3-FLUOROPYRIDINE;2-Chloro-3-fluoropyr
• CAS NO: 17282-04-1
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;alkyl Fluorine| alkyl chloride;Fluorin-contained pyridine series;Pyridine;Halides;Heterocycles;Pyridines;Boronic Acid;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Variety of halogenated heterocyclic series
• Mol File: 17282-04-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 80 °C80 mm Hg(lit.)
• Flash Point: 147 °F
• Appearance: Colorless to light yellow liquid
• Density: 1.323 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.63mmHg at 25°C
• Refractive Index: n20/D 1.509(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.05±0.10(Predicted)
• BRN: 1363435
• CAS DataBase Reference: 2-Chloro-3-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoropyridine(17282-04-1)
• EPA Substance Registry System: 2-Chloro-3-fluoropyridine(17282-04-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-41-36/37/38-37/38-23/24/25
• Safety Statements: 26-36-45-36/37/39
• RIDADR: 2810
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 17282-04-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C8F16O3/c9-1(25)2(10,11)26-7(21,22)8(23,24)27-6(19,20)4(14,15)3(12,13)5(16,17)18

Upstream product

• 372-47-4 3-Fluoropyridine 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 67-72-1 hexachloroethane 
• 462-08-8 pyridin-3-ylamine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 78948-09-1 acetyl hypofluorite 

Downstream Products

• 85386-84-1 1-(3-fluoro-pyridin-2-yl)piperazine 
• 455266-45-2 4-[(3-fluoro-pyridin-2-ylamino)-methyl]-piperidine-1-carboxylic acid benzyl ester 
• 146141-10-8 N-[2-(3-fluoropyridin-2-yl)phenyl]-2,2-dimethylpropionamide 
• 1184172-46-0 2-chloro-3-fluoro-4-hydroxypyridine 
• 946127-54-4 (2-chloro-3-fluoro-pyridin-4-yl)methanol 
• 1236770-00-5 1-(2-chloro-3-fluoro-4-pyridyl)ethanone 
• 1283090-75-4 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-ol 
• 1283090-73-2 7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine] 
• 1283090-95-8 N-[1-(3,4-difluorophenyl)-2,2-difluoro-1-{5-[(7-fluoro-1H,1'H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1'-yl)methyl]pyridin-2-yl}ethyl]acetamide 
• 1283090-94-7 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidine] 
• 1283090-74-3 1'-benzyl-6-chloro-7-fluoro-1H-spiro[furo[3,4-c]pyridine-3,4'-piperidin]-1-one 
• 1403396-37-1 8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-{1-[4-(3-fluoropyridin-2-yl)phenyl]cyclopropyl}-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine 
• 946127-56-6 dibenzylidene[4-(tert-butyldimethylsilyloxymethyl)-3-fluoropyridin-2-yl]amine 
• 946127-57-7 [2-(benzhydrylidene-amino)-3-fluoropyridin-4-yl]methanol 

Relevant articles and documents

Synthesis of 2-Alkylamino-3-fluoropyridines Using Buchwald Conditions

Synthesis of 2-alkylamino-3-fluoropyridines from 2-chloro-3-fluoropyridine using palladium-catalyzed coupling reaction under Buchwald conditions is described.

Thorpe–Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides

Presented herein is a general protocol for the alkylation of simple aryl fluorides with unbiased secondary Grignard reagents by means of nickel catalysis. This study revealed a general Thorpe–Ingold effect in the ligand backbone which confers a high degree of selectivity for the secondary carbon center in the C?C coupling event. This protocol is characterized by mild reaction conditions, robustness, and simplicity. Both electron-rich and electron-deficient aryl fluorides are suitable candidates in this transformation. Equally amenable are a variety of heterocycles, permitting the coupling without over alkylation at the electrophilic sites.

Benzimidazoles that are useful in treating sexual dysfunction

The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction.