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174727-36-7

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174727-36-7 Usage

General Description

ETHYL 3-(2,6-DICHLOROPYRIDIN-3-YL)-3-OXOPROPANOATE is an organic compound with the chemical formula C11H9Cl2NO3. It is a ester derivative of pyridine, containing two chlorine atoms in the 2 and 6 positions. ETHYL 3-(2,6-DICHLOROPYRIDIN-3-YL)-3-OXOPROPANOATE is commonly used in the development of pharmaceuticals and agrochemicals due to its potential biological activities. It has been found to have insecticidal, fungicidal and bactericidal properties, making it a useful component in the creation of pesticides. Additionally, it is also used as an intermediate in the fabrication of other organic compounds and has applications in research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 174727-36-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,7,2 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 174727-36:
(8*1)+(7*7)+(6*4)+(5*7)+(4*2)+(3*7)+(2*3)+(1*6)=157
157 % 10 = 7
So 174727-36-7 is a valid CAS Registry Number.

174727-36-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ETHYL 3-(2,6-DICHLOROPYRIDIN-3-YL)-3-OXOPROPANOATE

1.2 Other means of identification

Product number -
Other names QC-1758

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:174727-36-7 SDS

174727-36-7Relevant articles and documents

Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives

Srivastava, Sanjay K.,Jaggi, Manu,Singh, Anu T.,Madan, Alka,Rani, Nidhi,Vishnoi, Manupriya,Agarwal, Shiv K.,Mukherjee, Rama,Burman, Anand C.

, p. 6660 - 6664 (2007)

Several 1,8-naphthyridine-3-carboxamide derivatives (8-23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50 = 1.37 μM) in HBL-100 (breast) cell line while compounds 17 (IC50 = 3.7 μM) and 22 (IC50 = 3.0 μM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.

Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives

Jia, Xue-Dong,Wang, Shuo,Wang, Ming-Hua,Liu, Ming-Liang,Xia, Gui-Min,Liu, Xiu-Jun,Chai, Yun,He, Hong-Wei

supporting information, p. 235 - 239 (2017/01/28)

A series of naphthyridinone derivatives based on 1a (a precursor of Voreloxin) were designed and synthesized. Seven compounds having >70% inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro antitumor activity by SRB assay. Results reveal that thiazol-2-yl and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-1-yl groups are optimal at the N-1 and C-7 positions of naphthyridinone core, respectively. 10j exhibits broad-spectrum activity (IC50: 100-fold more potent than the two references against eight of these cell lines.

STABLE SNS-595 COMPOSITIONS AND METHODS OF PREPARATION

-

Page/Page column 53; 54, (2011/04/14)

Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.

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