174727-36-7Relevant articles and documents
Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives
Srivastava, Sanjay K.,Jaggi, Manu,Singh, Anu T.,Madan, Alka,Rani, Nidhi,Vishnoi, Manupriya,Agarwal, Shiv K.,Mukherjee, Rama,Burman, Anand C.
, p. 6660 - 6664 (2007)
Several 1,8-naphthyridine-3-carboxamide derivatives (8-23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC50 = 1.37 μM) in HBL-100 (breast) cell line while compounds 17 (IC50 = 3.7 μM) and 22 (IC50 = 3.0 μM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.
Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives
Jia, Xue-Dong,Wang, Shuo,Wang, Ming-Hua,Liu, Ming-Liang,Xia, Gui-Min,Liu, Xiu-Jun,Chai, Yun,He, Hong-Wei
supporting information, p. 235 - 239 (2017/01/28)
A series of naphthyridinone derivatives based on 1a (a precursor of Voreloxin) were designed and synthesized. Seven compounds having >70% inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro antitumor activity by SRB assay. Results reveal that thiazol-2-yl and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-1-yl groups are optimal at the N-1 and C-7 positions of naphthyridinone core, respectively. 10j exhibits broad-spectrum activity (IC50: 100-fold more potent than the two references against eight of these cell lines.
STABLE SNS-595 COMPOSITIONS AND METHODS OF PREPARATION
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Page/Page column 53; 54, (2011/04/14)
Methods of preparing substantially pure SNS-595 substance are disclosed. Also provided are compositions comprising SNS-595 substance that are substantially pure and essentially free of visible particles.