175221-03-1

Basic information

• Product Name: (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid
• Synonyms: (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid;(1S,2S)-Cyclopropane-1,2-dicarboxylic Acid MonoMenthyl Ester;(1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid-5
• CAS NO: 175221-03-1
• Molecular Formula: C₁₅H₂₄O₄
• Molecular Weight: 268.34866
• Product Categories: Aliphatics, Miscellaneous Reagents
• Mol File: 175221-03-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 379.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.11±0.1 g/cm3(Predicted)
• PKA: 4.07±0.11(Predicted)
• CAS DataBase Reference: (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid(175221-03-1)
• EPA Substance Registry System: (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-Methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid(175221-03-1)

Safety Data

• Hazardous Substances Data: 175221-03-1(Hazardous Substances Data)

Usage

Uses

(1S,2S)-Cyclopropane-1,2-dicarboxylic Acid Monomenthyl Ester was used in the synthetic preparation of Callipeltoside A, a compound that exerts cytotoxicity again human bronchopulmonary non-small cell lung carcinoma.

Upstream product

• 96149-00-7 (1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester 
• 34212-59-4 bis(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl butanedioate 

Downstream Products

• 178684-64-5 (1S,2S)-2-[(R)-4-(2,2-Diphenyl-ethyl)-1-(4-methoxy-benzyl)-2,5-dioxo-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester 
• 178898-44-7 (1S,2S)-2-[(S)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester 
• 201851-10-7 (1S,2S)-2-(2-9H-Xanthen-9-yl-acetyl)-cyclopropanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 178684-63-4 (1S,2S)-2-(3,3-Diphenyl-propionyl)-cyclopropanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 201851-15-2 (1S,2S)-2-[(R)-1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acid 
• 178898-39-0 5R-5-(1S,2S-2-carboxycyclopropan-1-yl)-5-(2,2-(diphenyl)ethyl)imidazolidine-2,4-dione 
• 201851-27-6 (5SR)-5-((1S,2S)-2-carboxycycloprop-1-yl)-5-(2,2-diphenylethyl)imidazolidine-2,4-dione 
• 178684-67-8 (1S,2S)-2-(3-m-Tolyl-propionyl)-cyclopropanecarboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 203208-44-0 (1S,2S)-2-(2-9H-Xanthen-9-yl-acetyl)-cyclopropanecarboxylic acid 
• 201851-22-1 (5SR)-5-((1S,2S)-2-carboxycycloprop-1-yl)-5-[2-(3-methylphenyl)ethyl]imidazolidine-2,4-dione 
• 178898-37-8 (1S,2S-2-carboxycycloprop-1-yl) (2,2-(diphenyl)ethyl) ketone 
• 178898-43-6 (1S,2S-2-carboxycycloprop-1-yl) (2-(3-methylphenyl)ethyl) ketone 
• 203209-15-8 (1S,2S)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester 
• 329025-42-5 (2S,1'S,2'S)-N-[(R)-α-phenylglycinol]-[2'-carbomenthyloxycyclopropyl]-glycinonitrile 

Relevant articles and documents

RADIOLABELED CANNABINOID RECEPTOR 2 LIGAND

The present invention relates to a compound of formula (I) wherein R1, R2, and R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a radiolabeled ligand.

PYRIDINE AND PYRAZINE DERIVATIVES AS PREFERENTIAL CANNABINOID 2 AGONISTS

The invention relates to a compound of formula (I), wherein A1, A2 and R1-R5 are as defined in the description and in the claims. The compound of formula (I) can be used as cannabinoid 2 preferential agonist.

Callipeltoside A: assignment of absolute and relative configuration by total synthesis.

-