(1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid
CAS No.:175221-03-1
Molecular Formula:C15H24O4
Molecular Weight:268.353
Hs Code.:
Mol file:175221-03-1.mol

Synonyms:ethyl tetrahydro-2H-pyran-2-carboxylate;(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester;tetrahydro-pyran-2-carboxylic acid ethyl ester;2H-Pyran-2-carboxylic acid,tetrahydro-,ethyl ester;Tetrahydro-pyran-2-carbonsaeure-aethylester;2-carboethoxy-tetrahydro-pyran;tetrahydropyranic ether;2-carbomenthyloxy (1S,2S)-cyclopropane-1-carboxylic acid;

Suppliers and Price of (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S,2S)-Cyclopropane-1,2-dicarboxylicAcidMonomenthylEster
250mg
$ 185.00

ChemScene
(1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylicacid
25mg
$ 209.00

Total 8 raw suppliers

Chemical Property of (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid

Chemical Property:

Boiling Point:379.3±35.0 °C(Predicted)
PKA:4.07±0.11(Predicted)
PSA：63.60000
Density:1.11±0.1 g/cm3(Predicted)
LogP:2.71110

Purity/Quality:

≥95% ^*data from raw suppliers

(1S,2S)-Cyclopropane-1,2-dicarboxylicAcidMonomenthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (1S,2S)-Cyclopropane-1,2-dicarboxylic Acid Monomenthyl Ester was used in the synthetic preparation of Callipeltoside A, a compound that exerts cytotoxicity again human bronchopulmonary non-small cell lung carcinoma.

Technology Process of (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid

There total 3 articles about (1S,2S)-2-(((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 96149-00-7
(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

: 175221-03-1
(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: With sodium hydroxide; In isopropyl alcohol; at 50 - 85 ℃;
DOI:10.1016/S0957-4166(00)00434-1

Reference yield:

: C₁₉H₃₂O₄

: (1R,2R)‐2‐((((1R,2S,5R)‐2‐isopropyl‐5‐methylcyclohexyl)oxy)carbonyl)cyclopropane‐1‐carboxylic acid

: 175221-03-1
(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h; Overall yield = 1.3 g;
DOI:10.1246/bcsj.20190168

Reference yield:

: 34212-59-4,96149-05-2
bis(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl butanedioate

: 175221-03-1
(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: LiTMP / tetrahydrofuran; hexane / 4 h / -78 °C

2: NaOH / propan-2-ol; H₂O / 70 °C

With sodium hydroxide; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexane; water; isopropyl alcohol;
DOI:10.1021/ja0205232