17780-72-2 Usage
Uses
Used in Pharmaceutical Industry:
CLORGYLINE is used as a monoamine oxidase inhibitor for its antidepressant properties. It was utilized in the treatment of depression by increasing the levels of monoamines in the brain, thereby improving mood and reducing symptoms of depression.
Used in Research Applications:
CLORGYLINE is used as a research tool for studying the role of monoamine oxidase in various biological processes and its involvement in the pathophysiology of mood disorders. It helps researchers understand the mechanisms of action of antidepressant drugs and their potential therapeutic applications.
Used in Drug Development:
CLORGYLINE serves as a lead compound in the development of new and improved monoamine oxidase inhibitors with better efficacy, safety, and fewer side effects. Its chemical structure and pharmacological properties provide valuable insights for the design of novel antidepressant drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 17780-72-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,8 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17780-72:
(7*1)+(6*7)+(5*7)+(4*8)+(3*0)+(2*7)+(1*2)=132
132 % 10 = 2
So 17780-72-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
17780-72-2Relevant articles and documents
From Anilines to Aryl Ethers: A Facile, Efficient, and Versatile Synthetic Method Employing Mild Conditions
Wang, Dong-Yu,Yang, Ze-Kun,Wang, Chao,Zhang, Ao,Uchiyama, Masanobu
, p. 3641 - 3645 (2018/03/13)
We have developed a simple and direct method for the synthesis of aryl ethers by reacting alcohols/phenols (ROH) with aryl ammonium salts (ArNMe3+), which are readily prepared from anilines (ArNR′2, R′=H or Me). This reaction proceeds smoothly and rapidly (within a few hours) at room temperature in the presence of a commercially available base, such as KOtBu or KHMDS, and has a broad substrate scope with respect to both ROH and ArNR′2. It is scalable and compatible with a wide range of functional groups.
Synthesis of fluorine and iodine analogues of clorgyline and selective inhibition of monoamine oxidase A
Ohmomo,Hirata,Murakami,Magata,Tanaka,Yokoyama
, p. 1038 - 1040 (2007/10/02)
A series of fluorine and iodine analogues of clorgyline was synthesized and evaluated for inhibitory potency and selectivity toward monoamine oxidase A (MAO-A). Among them, N-[3-(2,4-dichloro-6-iodophenoxy)propyl]-N-methyl-2-propynylamine (3d), N-[3-(4-ch
