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4-bromo-6-methoxyisoquinoline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1781486-94-9 Structure
  • Basic information

    1. Product Name: 4-bromo-6-methoxyisoquinoline
    2. Synonyms:
    3. CAS NO:1781486-94-9
    4. Molecular Formula:
    5. Molecular Weight: 238.084
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1781486-94-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-bromo-6-methoxyisoquinoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-bromo-6-methoxyisoquinoline(1781486-94-9)
    11. EPA Substance Registry System: 4-bromo-6-methoxyisoquinoline(1781486-94-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1781486-94-9(Hazardous Substances Data)

1781486-94-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1781486-94-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,8,1,4,8 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1781486-94:
(9*1)+(8*7)+(7*8)+(6*1)+(5*4)+(4*8)+(3*6)+(2*9)+(1*4)=219
219 % 10 = 9
So 1781486-94-9 is a valid CAS Registry Number.

1781486-94-9Downstream Products

1781486-94-9Relevant articles and documents

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity

Aoyagi, Atsushi,Conrad, Jay,Droege, Daniel G.,Elepano, Manuel,Grandjean, Jean-Marc M.,Hirano, Shimpei,Hirasawa, Makoto,Hirouchi, Masakazu,Inoue, Masahiro,Jiu, Alexander Y.,Lee, Joanne,Murakami, Ryo,Ohyama, Takao,Olson, Steven H.,Paras, Nick A.,Prusiner, Stanley B.,Sasaki, Koji,Tang, Benjamin C.,Vaz, Roy J.,West, John W.

, (2020)

Tau prions feature in the brains of patients suffering from Alzheimer's disease and other tauopathies. For the development of therapeutics that target the replication of tau prions, a high-content, fluorescence-based cell assay was developed. Using this high-content phenotypic screen for nascent tau prion formation, a 4-piperazine isoquinoline compound (1) was identified as a hit with an EC50 value of 390 nM and 0.04 Kp,uu. Analogs were synthesized using a hypothesis-based approach to improve potency and in vivo brain penetration resulting in compound 25 (EC50 = 15 nM; Kp,uu = 0.63). We investigated the mechanism of action of this series and found that a small set of active compounds were also CDK8 inhibitors.

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