178765-49-6

Basic information

• Product Name: Delta3,2-Hydroxylbakuchiol
• Synonyms: Delta3,2-Hydroxylbakuchiol;13-Hydroxyisobakuchiol;4-[(1E,3S,5E)-3-Ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadienyl]phenol
• CAS NO: 178765-49-6
• Molecular Formula: C18H24O2
• Molecular Weight: 272.38196
• Mol File: 178765-49-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Delta3,2-Hydroxylbakuchiol(CAS DataBase Reference)
• NIST Chemistry Reference: Delta3,2-Hydroxylbakuchiol(178765-49-6)
• EPA Substance Registry System: Delta3,2-Hydroxylbakuchiol(178765-49-6)

Safety Data

• Hazardous Substances Data: 178765-49-6(Hazardous Substances Data)

Usage

General Description

Delta3,2-Hydroxylbakuchiol is a natural chemical compound derived from the seeds of the Psoralea corylifolia plant, also known as the babchi plant. It is a bakuchiol analog that has been found to have potent anti-aging and skin-regenerating properties. Delta3,2-Hydroxylbakuchiol has been shown to stimulate collagen and elastin production, which helps to improve skin elasticity and reduce the appearance of wrinkles and fine lines. Additionally, it exhibits anti-inflammatory and antioxidant properties, making it a valuable ingredient in skincare products for promoting overall skin health and combating signs of aging. Studies have also indicated that Delta3,2-Hydroxylbakuchiol is well-tolerated and safe for topical use, making it a promising alternative to retinoids in skincare formulations.

Upstream product

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• 1492056-94-6 (S,E)-ethyl 5-formyl-5-methylhepta-2,6-dienoate 
• 1492056-92-4 (S,E)-ethyl 5-(hydroxymethyl)-5-methylhepta-2,6-dienoate 
• 1492056-91-3 (S,E)-ethyl 5-(((tert-butyldimethylsilyl)oxy)methyl)-5-methylhepta-2,6-dienoate 
• 1492056-89-9 (S)-tert-butyl 3-(((tert-butyldimethylsilyl)oxy)methyl)-3-methylpent-4-enoate 
• 1492056-88-8 (S)-tert-butyl 3-(hydroxymethyl)-3-methylpent-4-enoate 
• 1492056-85-5 (S)-tert-butyl 3-((R)-4-isopropyl-2-oxooxazolidine-3-carbonyl)-3-methylpent-4-enoate 
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Relevant articles and documents

Δ3 Asymmetric synthesis method -2 - hydroxyl psoralen and analogue compound

The invention belongs to the field of chemical synthesis, provides a novel method for synthesizing delta3-2-hydroxybakuchiol and particularly relates to an asymmetric synthesis method for delta3-2-hydroxybakuchiol and analog compounds. The delta3-2-hydroxybakuchiol and the analog compounds, the general formula of which is (I), are synthesized by an asymmetric synthesis route. Problems in the prior art, that the content of the delta3-2-hydroxybakuchiol obtained by extraction and separation from plants is very low, an extraction rate is very low, the delta3-2-hydroxybakuchiol is prone to oxidative deterioration in extraction and separation processes, and the like, are overcome by the method. The method can provide sufficient samples for related pharmaceutical research, and provides good foundations for pharmaceutical research on antibiosis, infection resistance, oxidation resistance, pigment deposition resistance, reduction of bone loss, immunosuppression, liver damage, sedation and hypnosis, and the like. In the formula (I), R1 is selected from 4-hydroxy, 3-hydroxy, 2-hydroxy, hydrogen, 4-methyl, 4-methoxy, 4-trifluoromethyl, 3,4-[d][1,3]dioxole, and 3,4-phenyl; R2 is selected from methyl, ethyl, and butyl; and R3 is selected from vinyl, ethyl and cyclopropyl.

Anti-proliferative effect of synthesized bakuchiol analogues on cultured human tumor cell lines

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