1809-19-4Relevant articles and documents
Trialkyl Phosphite Addition to the Bis(benzene)-iron(II) and -ruthenium(II) Dications: Catalysed Hydrolysis to Dialkyl Phosphites
Sweigart, Dwight A.
, p. 1159 - 1160 (1980)
Phosphite addition to 2+ (M = Fe,Ru) yields cyclohexadienyl phosphonium and phosphonate adducts that catalyse the conversion of excess of phosphite into HP(O)(OR)2 and RP(O)(OR)2.
Synthesis and characterization of new symmetrical bisphosphonates
Marques Rodrigues, Janaina,DaCosta, Joao Batista Neves
, p. 137 - 149 (2002)
In order to search for new chelating agents, widely employed methodologies in the chemistry of organophosphorus compounds such as the Michaelis-Arbuzov and Michaelis-Becker reactions were used to synthesize new bisphosphonates in high yields. The importance of the synthesis of these compounds resides in their potential capability of complexing different metals, all the more so because bisphosphonates have been widely employed in the diagnosis and therapy of several bone diseases, such as osteoporosis and hypercalcemia, as extracting agents for alkaline, alkaline earth, and transition metals, and also as reaction catalysts. All bisphosphonates synthesized were characterized by IR, 1H-NMR, 13C-NMR, 31P-NMR, and mass spectroscopy.
Method for preparing phosphite diester by transesterification
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Paragraph 0023, (2020/01/25)
The invention discloses a method for preparing phosphite diester by transesterification. Dimethyl phosphite and monohydric alcohol which are used as raw materials are stirred, reacted and rectified under the action of a basic catalyst to prepare the phosphite diester, so the problems of high deice requirements and large amount of acid-containing three wastes in the process of producing the phosphite diester by reacting phosphorus trichloride with alcohol are avoided. The method has the advantages of low raw material toxicity, simple process, mild reaction conditions, low device requirements, low pollution, high raw material conversion rate, high product selectivity, stable supply of the raw materials, provision of the phosphite diester used for fine chemical engineering or medical intermediates by dimethyl phosphite production enterprises, high added values of the product, and provision of a new way for the synthesis of the phosphite diester.
Synthesis of phosphonates in a continuous flow manner
Tóth, Nóra,Tajti, ádám,Ladányi-Pára, Katalin,Bálint, Erika,Keglevich, Gy?rgy
, p. 285 - 286 (2019/03/11)
The synthesis of dialkyl H-phosphonates and α-aminophosphonates was studied in a continuous flow microwave reactor. Depending on the conditions, the alcoholysis of dialkyl H-phosphonates could be fine-tuned towards the mixed and the fully transesterified products. The continuous flow synthesis of α-aryl-α-aminophosphonates was elaborated utilizing the aza-Pudovik reaction of imines and dialkyl H-phosphonates, as well as the by the Kabachnik-Fields condensation of primary amines, benzaldehyde and > P(O)H reagents.
