18158-16-2 Usage
General Description
1-Cbz-[1,4]diazepan-5-one, also known as carbobenzoxy-1,4-diazepan-5-one, is a chemical compound with the molecular formula C14H17N3O2. It is a heterocyclic compound that contains a seven-membered ring with two nitrogen atoms and an oxygen atom. 1-Cbz-[1,4]diazepan-5-one is commonly used as a building block in organic synthesis and is often employed in the production of pharmaceuticals, particularly as a precursor in the synthesis of various drugs. 1-Cbz-[1,4]diazepan-5-one has also been studied for its potential therapeutic applications in the treatment of various medical conditions, making it a valuable chemical in the field of medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 18158-16-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,5 and 8 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 18158-16:
(7*1)+(6*8)+(5*1)+(4*5)+(3*8)+(2*1)+(1*6)=112
112 % 10 = 2
So 18158-16-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H16N2O3/c16-12-6-8-15(9-7-14-12)13(17)18-10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H,14,16)
18158-16-2Relevant articles and documents
Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided
Zhao, Jianhong,Wang, Dingding,Yang, Wu-Lin,Niu, Jinming,Wu, Weiting
, p. 91 - 96 (2021/12/06)
An efficient, robust, and cost-effective synthetic process of fasudil hydrochloride 1 was developed. Starting from readily available ethylenediamine and 5-isoquinoline sulfonyl chloride, the target product 1 was prepared through a six-step reaction, including sulfonamidation, protection, nucleophilic substitution, deprotection, cyclization, and salification. The process afforded 1 in 67.1% overall yield (based on 5-isoquinoline sulfonyl chloride) with 99.94% purity. Compared to the earlier published methodologies, the use of homopiperazine or its derivatives as intermediates was avoided. The salient features of this environmentally friendly synthetic route include easily available starting materials and operational simplicity, which could be suitable for large-scale industrial production.