344779-07-3 Usage
General Description
The chemical 4-(2-Dimethylamino-ethyl)-[1,4]diazepan-5-one, also known as etizolam, is a psychoactive drug belonging to the thienodiazepine class. It is used for its sedative, hypnotic, and anxiolytic properties and has been marketed as a prescription medication in several countries for the treatment of anxiety disorders and insomnia. Etizolam acts on the central nervous system by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA), resulting in a calming and tranquilizing effect. However, it also has the potential for abuse and dependence, and its use should be carefully monitored by healthcare professionals. Its legal status varies by country, with some places regulating it as a controlled substance due to its psychoactive effects.
Check Digit Verification of cas no
The CAS Registry Mumber 344779-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,7,7 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 344779-07:
(8*3)+(7*4)+(6*4)+(5*7)+(4*7)+(3*9)+(2*0)+(1*7)=173
173 % 10 = 3
So 344779-07-3 is a valid CAS Registry Number.
344779-07-3Relevant articles and documents
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD)
Moffett, Kristofer,Konteatis, Zenon,Nguyen, Duyan,Shetty, Rupa,Ludington, Jennifer,Fujimoto, Ted,Lee, Kyoung-Jin,Chai, Xiaomei,Namboodiri, Haridasan,Karpusas, Michael,Dorsey, Bruce,Guarnieri, Frank,Bukhtiyarova, Marina,Springman, Eric,Michelotti, Enrique
, p. 7155 - 7165 (2012/01/15)
Discovery of a new class of DFG-out p38α kinase inhibitors with no hinge interaction is described. A computationally assisted, virtual fragment-based drug design (vFBDD) platform was utilized to identify novel non-aromatic fragments which make productive hydrogen bond interactions with Arg 70 on the αC-helix. Molecules incorporating these fragments were found to be potent inhibitors of p38 kinase. X-ray co-crystal structures confirmed the predicted binding modes. A lead compound was identified as a potent (p38α IC50 = 22 nM) and highly selective (≥150-fold against 150 kinase panel) DFG-out p38 kinase inhibitor.
