344779-07-3 Usage
Uses
Used in Pharmaceutical Industry:
4-(2-Dimethylamino-ethyl)-[1,4]diazepan-5-one is used as a prescription medication for the treatment of anxiety disorders and insomnia. It is utilized for its sedative, hypnotic, and anxiolytic properties, which help alleviate symptoms associated with these conditions.
Used in Central Nervous System Regulation:
In the field of central nervous system regulation, 4-(2-Dimethylamino-ethyl)-[1,4]diazepan-5-one is used as a therapeutic agent to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA). This results in a calming and tranquilizing effect, which is beneficial for individuals suffering from anxiety and insomnia.
Used in Controlled Substances Regulation:
Due to its psychoactive effects and potential for abuse and dependence, 4-(2-Dimethylamino-ethyl)-[1,4]diazepan-5-one is used in the context of controlled substances regulation in various countries. This ensures that its use is carefully monitored and restricted to prevent misuse and promote responsible medical practices.
Check Digit Verification of cas no
The CAS Registry Mumber 344779-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,4,7,7 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 344779-07:
(8*3)+(7*4)+(6*4)+(5*7)+(4*7)+(3*9)+(2*0)+(1*7)=173
173 % 10 = 3
So 344779-07-3 is a valid CAS Registry Number.
344779-07-3Relevant academic research and scientific papers
Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD)
Moffett, Kristofer,Konteatis, Zenon,Nguyen, Duyan,Shetty, Rupa,Ludington, Jennifer,Fujimoto, Ted,Lee, Kyoung-Jin,Chai, Xiaomei,Namboodiri, Haridasan,Karpusas, Michael,Dorsey, Bruce,Guarnieri, Frank,Bukhtiyarova, Marina,Springman, Eric,Michelotti, Enrique
, p. 7155 - 7165 (2012/01/15)
Discovery of a new class of DFG-out p38α kinase inhibitors with no hinge interaction is described. A computationally assisted, virtual fragment-based drug design (vFBDD) platform was utilized to identify novel non-aromatic fragments which make productive hydrogen bond interactions with Arg 70 on the αC-helix. Molecules incorporating these fragments were found to be potent inhibitors of p38 kinase. X-ray co-crystal structures confirmed the predicted binding modes. A lead compound was identified as a potent (p38α IC50 = 22 nM) and highly selective (≥150-fold against 150 kinase panel) DFG-out p38 kinase inhibitor.
