184719-80-0

Basic information

• Product Name: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE
• Synonyms: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE;h-d-pro-ptbu.hcl;H-D-Pro-OtBu. HCl ForM;D-Proline tert-butyl ester HCl;D-Proline tert-Butyl Ester Hydrochloride;(R)-Pyrrolidine-2-carboxylic acid tert-butyl ester hydrochloride;D-Prolinetert-butyl ester hydrochloride≥ 98% (HPLC);D-Proline, 1,1-dimethylethyl ester, hydrochloride (1:1)
• CAS NO: 184719-80-0
• Molecular Formula: C9H17NO2.HCl
• Molecular Weight: 0
• Product Categories: Amino Acid tert-Butyl Esters;Amino Acids;Amino Acids (C-Protected);Biochemistry
• Mol File: 184719-80-0.mol

Chemical Properties

• Melting Point: 94 °C
• Appearance: /
• Refractive Index: 31 ° (C=1, H2O)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Soluble in water
• CAS DataBase Reference: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE(184719-80-0)
• EPA Substance Registry System: D-PROLINE TERT-BUTYL ESTER HYDROCHLORIDE(184719-80-0)

Safety Data

• Hazardous Substances Data: 184719-80-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C9H17NO2.ClH/c1-9(2,3)12-8(11)7-5-4-6-10-7;/h7,10H,4-6H2,1-3H3;1H/t7-;/m1./s1

Upstream product

• 115-11-7 isobutene 
• 147-85-3 L-proline 
• 2812-46-6 proline tert-butyl ester 
• 91237-84-2 N-BOC-proline tert-butyl ester 

Downstream Products

• 24277-16-5 (S)-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylate 
• 111491-71-5 (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 1380236-70-3 C₂₂H₃₂N₂O₅ 
• 1462366-64-8 tert-butyl (S)-1-((3-chlorophenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylate 
• 1462366-57-9 tert-butyl (S)-1-((4-chlorophenyl)(methyl)carbamoyl)pyrrolidine-2-carboxylate 
• 1033708-07-4 tert-butyl (2S)-1-{[(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-L-prolinate 
• 111491-72-6 (S)-1-(2-{[(S)-1-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-acetyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 59834-37-6 (S)-1-(Pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid 
• 82213-52-3 Z-Phe-D-Val-Pro-OBu^t 
• 82213-51-2 Z-Phe-Val-Pro-OBu^t 
• 1056010-54-8 (R) proline, 1-[[4-chloro-2-[[6-(4-aminobutoxy)-7-methoxy-4-quinazolinyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester 
• 1085838-63-6 (R)-1-(4-{5-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-pyridin-2-yl}-benzoyl)-pyrrolidine-2-carboxylic acid 

Relevant articles and documents

STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS

The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.