18522-92-4Relevant articles and documents
Enhancement of the Antioxidant Activity and Neurotherapeutic Features through Pyridol Addition to Tetraazamacrocyclic Molecules
Johnston, Hannah M.,Pota, Kristof,Barnett, Madalyn M.,Kinsinger, Olivia,Braden, Paige,Schwartz, Timothy M.,Hoffer, Emily,Sadagopan, Nishanth,Nguyen, Nam,Yu, Yu,Gonzalez, Paulina,Tircsó, Gyula,Wu, Hongli,Akkaraju, Giridhar,Chumley, Michael J.,Green, Kayla N.
, p. 16771 - 16784 (2019)
Alzheimer's and other neurodegenerative diseases are chronic conditions affecting millions of individuals worldwide. Oxidative stress is a consistent component described in the development of many neurodegenerative diseases. Therefore, innovative strategi
A NOVEL AND ECONOMICAL PROCESS FOR PREPARING (S,S)-2, 8-DIAZABICYCLO[4.3.0]NONANE AND ITS ENANTIOMER
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Page/Page column 7-8, (2008/12/07)
The present invention relates to a novel and economical process for preparing (S, S)-2, 8-diazabicyclo[4.3.0]nonane, a valuable intermediate used for constructing quinolone and naphthyridine derivatives having antibacterial effectiveness,e.g. moxifloxacin and its enantiomer.
Concave Macroheterocycles
Mekelburger, Hans-Bernhard,Gross, Jens,Schmitz, Juergen,Nieger, Martin,Voegtle, Fritz
, p. 1713 - 1722 (2007/10/02)
Macrocyclic compounds of the general type 2 having a spherical shape and a molecular cavity have been synthesized.A "fold and paste"-type cyclization step generates the macroheterocycles 4,10,11,14, and 21.Since this approach is difficult to apply for O-substituted derivatives, the "spheriphane" 24 was synthesized by intermolecular cyclization.The X-ray structure analysis of 11 shows intermolecular interactions ("dimer formation") in the crystal. Key Words: Concave molecules/ Cyclophanes/ High-dilution principle/ Macrocycles/ Spheriphanes