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Usage

Uses

Used in Pharmaceutical Industry:
4-methyl-N-(methylcarbamoyl)benzenesulfonamide is used as a sulfonamide antibiotic for the treatment and prevention of various bacterial infections. Its ability to inhibit bacterial folic acid synthesis makes it an effective agent against a range of bacterial pathogens.
Used in Agricultural Applications:
In agriculture, 4-methyl-N-(methylcarbamoyl)benzenesulfonamide is used as an antimicrobial agent to control the spread of infectious diseases among crops and livestock. Its broad-spectrum antimicrobial activity helps in reducing the incidence of bacterial infections in plants and animals, thereby improving overall health and productivity.
Used in Veterinary Medicine:
4-methyl-N-(methylcarbamoyl)benzenesulfonamide is used as a therapeutic agent in veterinary medicine for the treatment of bacterial infections in animals. Its antimicrobial properties make it a valuable tool in managing and preventing the spread of infectious diseases among various animal species.

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 74-89-5 methylamine 
• 18522-92-4 sodium p-toluenesulfonamide 
• 96-31-1 N,N'-Dimethylurea 
• 46376-50-5 N-methyl-N'-(toluene-4-sulfonyl)-thiourea 

Relevant academic research and scientific papers

Protonation and anion-binding properties of aromatic sulfonylurea derivatives

In this work the anion-binding properties of three aromatic sulfonylurea derivatives in acetonitrile and dimethyl sulfoxide were explored by means of NMR titrations. It was found that the studied receptors effectively bind anions of low basicity (Cl?, Br?, I?, NO3?and HSO4?). The stoichiometry of the complexes with receptors containing one binding site was 1?:?1 exclusively, whereas in the case of the receptor containing two sulfonylurea groups 1?:?2 (receptor?:?anion) complexes were also detected in some cases. The presence of strongly basic anions (acetate and dihydrogen phosphate) led to the deprotonation of the sulfonylurea moiety. This completely hindered its anion-binding properties in DMSO and only proton transfer occurred upon the addition of basic anions to the studied receptors. In MeCN, a complex system of equilibria including both ligand deprotonation and anion binding was established. Since ionisation of receptors was proven to be a decisive factor defining the behaviour of the sulfonylurea receptors, their pKavalues were determined using several deprotonation agents in both solvents. The results were interpreted in the context of receptor structures and solvent properties and applied for the identification of the interactions with basic anions.