13909-69-8

Basic information

• Product Name: 4-methyl-N-(methylcarbamoyl)benzenesulfonamide
• CAS NO: 13909-69-8
• Molecular Formula: C₉H₁₂N₂O₃S
• Molecular Weight: 228.2682
• Mol File: 13909-69-8.mol
• Article Data: 3

Chemical Properties

• Density: 1.277g/cm³
• Refractive Index: 1.549
• CAS DataBase Reference: 4-methyl-N-(methylcarbamoyl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(methylcarbamoyl)benzenesulfonamide(13909-69-8)
• EPA Substance Registry System: 4-methyl-N-(methylcarbamoyl)benzenesulfonamide(13909-69-8)

Safety Data

• Hazardous Substances Data: 13909-69-8(Hazardous Substances Data)

Usage

General Description

4-methyl-N-(methylcarbamoyl)benzenesulfonamide is a chemical compound with the molecular formula C9H12N2O3S. It is a sulfonamide derivative and is commonly used as a sulfonamide antibiotic in the treatment and prevention of various bacterial infections. The compound acts by inhibiting the synthesis of folic acid in bacteria, thereby disrupting their ability to produce essential proteins and ultimately leading to their death. 4-methyl-N-(methylcarbamoyl)benzenesulfonamide may also have potential applications in other fields such as agriculture and veterinary medicine, where its antimicrobial properties could be beneficial in controlling the spread of infectious diseases.

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 74-89-5 methylamine 
• 18522-92-4 sodium p-toluenesulfonamide 
• 96-31-1 N,N'-Dimethylurea 
• 46376-50-5 N-methyl-N'-(toluene-4-sulfonyl)-thiourea 

Relevant articles and documents

Protonation and anion-binding properties of aromatic sulfonylurea derivatives

In this work the anion-binding properties of three aromatic sulfonylurea derivatives in acetonitrile and dimethyl sulfoxide were explored by means of NMR titrations. It was found that the studied receptors effectively bind anions of low basicity (Cl?, Br?, I?, NO3?and HSO4?). The stoichiometry of the complexes with receptors containing one binding site was 1?:?1 exclusively, whereas in the case of the receptor containing two sulfonylurea groups 1?:?2 (receptor?:?anion) complexes were also detected in some cases. The presence of strongly basic anions (acetate and dihydrogen phosphate) led to the deprotonation of the sulfonylurea moiety. This completely hindered its anion-binding properties in DMSO and only proton transfer occurred upon the addition of basic anions to the studied receptors. In MeCN, a complex system of equilibria including both ligand deprotonation and anion binding was established. Since ionisation of receptors was proven to be a decisive factor defining the behaviour of the sulfonylurea receptors, their pKavalues were determined using several deprotonation agents in both solvents. The results were interpreted in the context of receptor structures and solvent properties and applied for the identification of the interactions with basic anions.

Binding of sulfonylurea-related compounds with bovine serum albumin

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