185345-46-4

Basic information

• Product Name: 3-broMo-5-fluoro-4-hydroxybenzaldehyde
• Synonyms: 3-broMo-5-fluoro-4-hydroxybenzaldehyde
• CAS NO: 185345-46-4
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.0078632
• Mol File: 185345-46-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 238.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.826±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.00±0.23(Predicted)
• CAS DataBase Reference: 3-broMo-5-fluoro-4-hydroxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-broMo-5-fluoro-4-hydroxybenzaldehyde(185345-46-4)
• EPA Substance Registry System: 3-broMo-5-fluoro-4-hydroxybenzaldehyde(185345-46-4)

Safety Data

• Hazardous Substances Data: 185345-46-4(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-fluoro-4-hydroxybenzaldehyde can be used to prepare derivatives to treat malignant tumor, as well as, CRTH2 receptor inhibitors to treat inflammatory disorders.

Upstream product

• 1394291-51-0 2-bromo-6-fluoro-4-cresol 
• 405-05-0 3-fluoro-4-hydroxybenzaldehyde 

Downstream Products

• 1283119-09-4 methyl 3-fluoro-2-hydroxy-5-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyrimidin-4-yl)benzoate 
• 1283119-07-2 3-fluoro-2-hydroxy-5-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyrimidin-4-yl)benzoic acid 
• 1283119-08-3 4-(3-bromo-5-fluoro-4-hydroxyphenyl)-5,6-diphenyl-3,4-dihydropyrimidin-2(1H)-one 

Relevant articles and documents

Efficient Co(OAc)2-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes

We reported an efficient ligand-free Co(OAc)2·4H 2O/NaOH/O2/ethylene glycol reaction system that enables selective aerobic oxidation of a wide range of substrates covering 2,6-di-EWG-, 2,3,6-tri-EWG-, 2-EWG-, and 2-EWG-6-EDG-substituted 4-cresols into the corresponding 4-hydroxybenzaldehydes. Based on the experimental investigations and well-defined p-benzoquinone methides, a plausible reaction mechanism was proposed. Considering the simplicity of the procedure and importance of the products, the methodology was expected to become a favorable and practical tool in related benzylic C(sp3)-H functionalization chemistry.

Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions

A hindered para-hydroxyl group-directed remote benzylic C(sp3)-H oxyfunctionalization has been developed for the straightforward transformation of 2,6-disubstituted 4-cresols, 4-alkylphenols, 4-hydroxybenzyl alcohols and 4-hydroxybenzyl alkyl ethers into various aromatic carbonyl compounds. The ligand- and additive-free Cu(OAc)2-catalyzed atmospheric oxidation mediated by ethylene glycol unlocks a facile, atom-economical, and environmentally benign C=O formation for the functionalization of primary and secondary benzyl groups. Due to the pharmaceutical importance of 4-hydroxybenzaldehydes and 4-hydroxyphenones, the methodology is expected to be of significant value for both fundamental research and practical applications.

BIARYL OXYACETIC ACID COMPOUNDS

The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds provided include those of the general formula I.