405-05-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-hydroxybenzaldehyde is used as a synthetic intermediate for the preparation of Roflumilast (R639700), a medication used to treat chronic obstructive pulmonary disease (COPD). It is specifically utilized in the synthesis of 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic Acid (C988720), which is an impurity and intermediate in the production process of Roflumilast. This application highlights its importance in the development of pharmaceutical compounds that address significant health concerns.
Used in Chemical Synthesis:
3-Fluoro-4-hydroxybenzaldehyde is also used as a key building block in the synthesis of various organic compounds due to its unique functional groups. Its fluorinated and hydroxylated structure allows for further chemical reactions and modifications, making it a versatile starting material for the creation of new molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 67-66-3 chloroform 
• 367-12-4 2-fluorophenol 
• 76-05-1 trifluoroacetic acid 
• 405-04-9 3-fluoro-4-hydroxybenzonitrile 

Downstream Products

• 346-62-3 3-fluoro-4-hydroxy-benzaldehyde-(2,4-dinitro-phenylhydrazone) 
• 1026127-44-5 3-fluoro-4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzaldehyde 
• 1026436-45-2 3-Fluoro-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-benzaldehyde 
• 716344-12-6 trifluoromethanesulfonic acid 2-fluoro-4-formylphenyl ester 
• 790663-15-9 3-fluoro-4-octyloxy-benzaldehyde 
• 55660-73-6 2-fluoro-1,4-hydroquinone 
• 865450-69-7 4-(2,2-dimethoxy-ethoxy)-3-fluoro-benzaldehyde 

Relevant academic research and scientific papers

Inhibition of Acyl-CoA: Cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules

A major effort in Alzheimers disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.

Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives

Boropinic acid is a natural isopentenyloxycinnamic acid extracted from the aerial parts of Boronia pinnata Sm. (Rutaceae) with soybean 5-lipoxygenase inhibitory activity. In this paper the topical anti-inflammatory activity of boropinic acid and some of its natural and semi-synthetic derivatives was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID50 = 0.18 ÷ 0.72 μmol/cm2) to that of the reference drug indomethacin (ID50 = 0.23 μmol/cm 2), a non-steroidal anti-inflammatory drug.