18681-52-2Relevant articles and documents
Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues
Gaidzik, Nikola,Kaiser, Anton,Kowalczyk, Danuta,Westerlind, Ulrika,Gerlitzki, Bastian,Sinn, Hans Peter,Schmitt, Edgar,Kunz, Horst
, p. 9977 - 9981 (2011)
A shot in the arm for cancer treatment: Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and al
Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing: N -acetyl modified STn derivatives as anticancer vaccines
Xiao, An,Zheng, Xiu-Jing,Song, Chengcheng,Gui, Yue,Huo, Chang-Xin,Ye, Xin-Shan
, p. 7226 - 7237 (2016)
Glycoprotein MUC1 is an attractive target for anti-tumor vaccine development. However, the weak immunogenicity of MUC1 remains a significant problem. To solve this problem, several STn derivatives with N-acetyl modifications were synthesized and incorporated into a 20-amino acid MUC1 tandem repeat sequence. The modified STn-MUC1 glycopeptides were further connected to a carrier protein keyhole limpet hemocyanin (KLH). The immunological effects of these synthetic vaccine conjugates were evaluated using the BALB/c mouse model. The results showed that vaccine V2 elicited higher titers of antibodies which cross-reacted with the native STn-MUC1 antigen. Moreover, the elicited antisera reacted with the STn-MUC1 antigen-positive tumor cells, indicating that the carbohydrate antigen modification strategy may hold potential to overcome the weak immunogenicity of natural MUC1 glycopeptides.
Design, synthesis and biological evaluation of sulfenimine cephalosporin sulfoxides as β-lactamase inhibitors
Zhang, Kai,Ding, Huai-Wei,Ju, Hao,Huang, Qi,Zhang, Li-Juan,Song, Hong-Rui,Fu, De-Cai
, p. 801 - 803 (2015/08/03)
Abstract A series of sulfenimine cephalosporin sulfoxide derivatives (7a-v) were designed, synthesized and evaluated for their inhibitory activity against TEM-1 and cephalosporinase in cell-free systems. Some of the tested compounds showed enhanced inhibi
Regioselective deacetylation and glycosylation in the synthesis of the sialyl lewis0 X tetrasaccharide, a key component of the recognition site of PSGL-1
Pudelko, MacIej,Kowalczyk, Danuta,Kunz, Horst
supporting information; body text, p. 3023 - 3026 (2011/02/26)
A high-yielding regioselective deprotection of three out of five hydroxy groups of a Lewis X trisaccharide, which proceeds under very mild basic conditions, and a regio- and stereoselective sialylation reaction enable an efficient access to the sialyl Lew