18749-30-9 Usage
Uses
Used in Pharmaceutical Industry:
6-Hydroxy-tryptophan is used as a precursor in the synthesis of serotonin for the development of medications targeting mood regulation and treatment of mood disorders. Its role in serotonin production makes it a valuable compound in the research and development of pharmaceuticals aimed at improving mental health.
Used in Sleep Aid Formulations:
6-Hydroxy-tryptophan is used as a sleep aid ingredient in formulations designed to improve sleep quality and address sleep disturbances. Its involvement in melatonin production contributes to its effectiveness in promoting restful sleep and regulating the sleep-wake cycle.
Used in Nutraceutical Industry:
6-Hydroxy-tryptophan is used as a dietary supplement in the nutraceutical industry to support overall well-being by enhancing mood, sleep, and appetite regulation. Its natural presence in the body and its role in neurotransmitter synthesis make it a popular choice for consumers seeking natural solutions for mental health and sleep support.
Used in Research and Development:
6-Hydroxy-tryptophan is used as a research compound in scientific studies exploring its potential therapeutic applications and mechanisms of action. Its involvement in neurotransmitter and hormone synthesis provides a foundation for investigating its effects on mood, sleep, and other physiological processes.
Used in Functional Foods and Beverages:
6-Hydroxy-tryptophan is used as an ingredient in functional foods and beverages designed to promote mental well-being and improve sleep quality. Its presence in these products aims to provide consumers with natural, health-promoting options for mood and sleep support.
Check Digit Verification of cas no
The CAS Registry Mumber 18749-30-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,7,4 and 9 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 18749-30:
(7*1)+(6*8)+(5*7)+(4*4)+(3*9)+(2*3)+(1*0)=139
139 % 10 = 9
So 18749-30-9 is a valid CAS Registry Number.
18749-30-9Relevant articles and documents
Synthesis and biological evaluation of 18F-labeled fluoroethoxy tryptophan analogues as potential PET tumor imaging agents
Chiotellis, Aristeidis,Muller, Adrienne,Mu, Linjing,Keller, Claudia,Schibli, Roger,Kramer, Stefanie D.,Ametamey, Simon M.
, p. 3839 - 3851 (2016/11/06)
As a continuation of our research efforts toward the development of tryptophan-based radiotracers for tumor imaging with positron emission tomography (PET), three new fluoroethoxy tryptophan analogues were synthesized and evaluated in vivo. These new tracers (namely, 4-(2-[18F]fluoroethoxy)-DL-tryptophan ([18F]4-FEHTP), 6-(2-[18F]fluoroethoxy)-DL-tryptophan ([18F]6-FEHTP), and 7-(2-[18F]fluoroethoxy)-DL-tryptophan ([18F]7-FEHTP) carry the fluoroethoxy side chain either at positions 4-, 6-, or 7- of the indole core. Reference compounds and precursors were synthesized by multistep approaches. Radiosynthesis was accomplished by no-carrier-added nucleophilic 18F-fluorination following either an indirect approach (O-alkylation of the corresponding hydroxytryptophan with [18F]fluoroethyltosylate) or a direct approach (nucleophilic [18F] fluorination using a protected mesyl precursor). Radiochemical yields (decay corrected) for both methods were in the range of 10-18%. Small animal PET imaging with xenograft-bearing mice revealed the highest tumor/background ratio for [18F]6-FEHTP which, in a direct comparison, outperformed the other two tryptophan tracers and also the well-established tyrosine analogue O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]L-FET). Investigation of the transport mechanism of [18F]6-FEHTP in small cell lung cancer cells (NCI-H69) revealed that it is most probably taken up exclusively via the large neutral amino acid transporter(s) (LAT).
