18759-96-1

Basic information

• Product Name: 3-Aminobenzylmethylamine
• Synonyms: 3-AMINOBENZYLMETHYLAMINE;3-AMINO-N-METHYLBENZYLAMINE;3-amino-n-monomethylbenzylamine;3-[(methylamino)methyl]aniline;3-Amino-N-benzylamine;3-methylaminomethylphenylamine;3-Amino-N-methylbenzylamine ,98％;BenzeneMethanaMine, 3-aMino-N-Methyl-
• CAS NO: 18759-96-1
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• EINECS: 414-570-7
• Product Categories: Amine;Amines
• Mol File: 18759-96-1.mol

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 248.868 °C at 760 mmHg
• Flash Point: 34 °C
• Appearance: /
• Density: 1.021 g/cm³
• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.72±0.10(Predicted)
• CAS DataBase Reference: 3-Aminobenzylmethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminobenzylmethylamine(18759-96-1)
• EPA Substance Registry System: 3-Aminobenzylmethylamine(18759-96-1)

Safety Data

• Hazard Codes: C,N
• Statements: 21/22-34-43-50/53
• Safety Statements: 26-36/37/39-45-60-61
• RIDADR: 3259
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 18759-96-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminobenzylmethylamine is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse medicinal compounds, enhancing the range of treatments available for various health conditions.
Used in Agrochemical Industry:
3-Aminobenzylmethylamine is utilized as a versatile intermediate in the production of agrochemicals, such as pesticides and herbicides. Its role in the synthesis of these chemicals helps improve agricultural productivity and crop protection, ensuring food security and sustainable farming practices.
Used in Organic Synthesis:
As a building block in organic synthesis, 3-Aminobenzylmethylamine is used for the preparation of a wide range of chemical compounds. Its reactivity and functional groups enable the formation of various organic molecules, which can be further utilized in different industries, including chemical manufacturing, materials science, and research.
It is important to handle 3-Aminobenzylmethylamine with care and take proper safety precautions when working with it in laboratory or industrial settings to ensure the safety of personnel and the environment.

InChI:InChI=1/C8H12N2/c1-10-6-7-3-2-4-8(9)5-7/h2-5,10H,6,9H2,1H3

Upstream product

• 67344-77-8 1-(3-bromophenyl)-N-methylmethanamine 
• 25900-61-2 3-amino-N-methylbenzamide 
• 39191-07-6 3-chloro-N-methylbenzylamine 

Relevant articles and documents

Mild and highly selective palladium-catalyzed monoarylation of ammonia enabled by the use of bulky biarylphosphine ligands and palladacycle precatalysts

A method for the Pd-catalyzed arylation of ammonia with a wide range of aryl and heteroaryl halides, including challenging five-membered heterocyclic substrates, is described. Excellent selectivity for monoarylation of ammonia to primary arylamines was achieved under mild conditions or at rt by the use of bulky biarylphosphine ligands (L6, L7, and L4) as well as their corresponding aminobiphenyl palladacycle precatalysts (3a, 3b, and 3c). As this process requires neither the use of a glovebox nor high pressures of ammonia, it should be widely applicable.

NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.

A P,N-Ligand for palladium-catalyzed ammonia arylation: Coupling of deactivated aryl chlorides, chemoselective arylations, and room temperature reactions

(Figure Presented) Amazing ammonia: A new air-stable P,N-ligand (Mor-DalPhos) is reported that enables the palladium-catalyzed crosscoupling of ammonia to a variety of aryl chloride and aryl tosylate substrates with high chemoselectivity and, for the first time, at room temperature (see scheme; Ad = adamantyl, Ts=para-toluenesulfonyl).

Synthesis of potent and selective 2-azepanone inhibitors of human tryptase

The serine protease tryptase has been associated with a broad range of allergic and inflammatory diseases and, in particular, has been implicated as a critical mediator of asthma. The inhibition of tryptase therefore has the potential to be a valuable therapy for asthma. The synthesis, employing solution phase parallel methods, and SAR of a series of novel 2-azepanone tryptase inhibitors are presented. A member of this series, 8t, was identified as a potent inhibitor of human tryptase (IC50=38 nM) with selectivity ≤330-fold versus related serine proteases (trypsin, plasmin, uPA, tPA, APC, alpha-thrombin, and FXa).