67344-77-8

Basic information

• Product Name: (3-BROMOBENZYL)METHYLAMINE
• Synonyms: (3-BROMOBENZYL)METHYLAMINE;3-BROMO-N-METHYLAMINE;3-BROMO-N-METHYLBENZYLAMINE;(3-Bromobenzyl)methylamine95%;N-Methyl-3-bromobenzylamine Hydrochloride;N-Methyl-3-bromobenzylamine;(3-Bromobenzyl)Methylamine 95%;(3-BROMOBENZYL)METHY
• CAS NO: 67344-77-8
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: Amines and Anilines;Halides;Polyamines;API intermediates;Amines;C8;Nitrogen Compounds
• Mol File: 67344-77-8.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 231-232 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.461 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0478mmHg at 25°C
• Refractive Index: n20/D 1.5650(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.32±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: (3-BROMOBENZYL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMOBENZYL)METHYLAMINE(67344-77-8)
• EPA Substance Registry System: (3-BROMOBENZYL)METHYLAMINE(67344-77-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 2
• Hazardous Substances Data: 67344-77-8(Hazardous Substances Data)

Usage

Uses

(3-Bromobenzyl)methylamine is a useful intermediate used in the preparation of 2,4-diamino-6-(benzylmethylamino)quinazolines with antimalarial and antitumor activities.

InChI:InChI=1/C8H10BrN/c1-10-6-7-3-2-4-8(9)5-7/h2-5,10H,6H2,1H3/p+1

Upstream product

• 823-78-9 meta-bromobenzyl bromide 
• 74-89-5 methylamine 
• 171663-13-1 t-butyl N-(3-bromobenzyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10269-01-9 3-bromobenzylamine 
• 932-77-4 3-bromobenzyl chloride 
• 3132-99-8 m-bromobenzoic aldehyde 
• 98760-22-6 C₈H₉Br₂N 
• 35003-56-6 m-Bromo-N-methylbenzylidenamin 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 876476-08-3 (3-bromo-benzyl)-(2-chloro-benzyl)-methyl-amine 
• 857825-62-8 (3-bromo-benzyl)-(3-iodo-benzyl)-methyl-amine 
• 93683-67-1 6-<<(3-bromophenyl)methyl>methylamino>-3-nitro-2-pyridinecarbonitrile 
• 70972-94-0 N-Chloro-N-methyl-m-bromobenzylamin 
• 98760-22-6 C₈H₉Br₂N 
• 98736-47-1 N-nitroso-N-(3-bromobenzyl)methylamine 
• 851534-89-9 N-(3-bromobenzyl)-N-methylacetamide 
• 1219090-05-7 C₁₆H₁₅N 
• 864061-96-1 C₁₈H₂₀BrN₅O₄ 
• 1092060-52-0 C₂₅H₂₄BrFN₂ 
• 1092060-64-4 C₂₆H₂₆BrFN₂ 
• 1177559-66-8 3-{[[(3-bromophenyl)methyl](methyl)amino]sulfonyl}benzoic acid 
• 1301198-93-5 1-Methylethyl ((2S,4R)-1-acetyl-2-methyl-6-{3-[(methylamino)methyl]phenyl}-1,2,3,4-tetrahydro-4-quinolinyl)carbamate 
• 18759-96-1 3-amino-N-methylbenzylamine 

Relevant articles and documents

FUSED PYRAZOLE DERIVATIVES AS JAK INHIBITORS

Novel fused pyrazole derivatives of Formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY

The present disclosure relates to compounds of formula I : compositions containing same and methods for treating or preventing a condition associated with brown adipose tissue dysfunction in a subject and/or for converting white adipose tissue into beige/

Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations

3H-1,3,4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H37Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial cytochrome P450-dependent sterol 14α-demethylase in the sterol biosynthesis pathway as the calculated free energy of binding were in agreement with the corresponding MIC values.