187803-40-3

Basic information

• Product Name: Benzaldehyde, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• Synonyms: 3,5-bis-(tert-butyldimethylsilanyloxy)benzaldehyde;3,5-bis-(tert-butyldimethylsilyloxy)benzaldehyde;3,5-di-(tert-butyldimethylsilyloxy)benzaldehyde;3,5-di(tert-butyldimethylsilanyloxy)benzaldehyde;3,5-di(tert-butyldimethylsilyloxy)benzaldehyde;3,5-bis(t-butyldimethylsiloxy)benzaldehyde;3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-benzaldehyde
• CAS NO: 187803-40-3
• Molecular Formula: C19H34O3Si2
• Molecular Weight: 366.648
• Mol File: 187803-40-3.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(187803-40-3)
• EPA Substance Registry System: Benzaldehyde, 3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(187803-40-3)

Safety Data

• Hazardous Substances Data: 187803-40-3(Hazardous Substances Data)

Upstream product

• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 103929-83-5 methyl 3,5-bis(tert-butyldimethylsilyloxy)benzoate 
• 103929-84-6 [3,5-di(tert-butyldimethylsilanyloxy)phenyl]methanol 

Downstream Products

• 252913-15-8 1-[3,5-bis-(tert-butyldimethylsilanyloxy)phenyl]non-2-yn-1-ol 
• 187803-41-4 ((5-(2,2-dibromovinyl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane) 
• 107030-46-6 C₂₆H₄₀O₂Si₂ 
• 192710-87-5 (E)-3,5-di-(tert-butyldimethylsilyloxy)-4'-methoxystilbene 
• 192710-88-6 (Z)-3,5-di-(tert-butyldimethylsilyloxy)-4'-methoxystilbene 
• 1428522-15-9 C₂₉H₂₀N₂O₉ 
• 1454785-50-2 1-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)but-3-en-1-ol 
• 1454785-70-6 1-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)prop-2-en-1-ol 
• 1454785-51-3 (5-(1-(tert-butyldimethylsilyloxy)but-3-enyl)-1,3-phenylene)bis(oxy)bis(tertbutyldimethylsilane) 

Relevant articles and documents

Small Molecule Inhibitors of the Bacterioferritin (BfrB)-Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells

Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe3+ in bacterioferritin and its subsequent mobilization as Fe2+ to satisfy metabolic requirements. In Pseudomonas aeruginosa Fe3+ is compartmentalized in bacterioferritin (BfrB), and its mobilization to the cytosol requires binding of a ferredoxin (Bfd) to reduce the stored Fe3+ and release the soluble Fe2+. Blocking the BfrB-Bfd complex in P. aeruginosa by deletion of the bfd gene triggers an irreversible accumulation of Fe3+ in BfrB, concomitant cytosolic iron deficiency and significant impairment of biofilm development. Herein we report that small molecules developed to bind BfrB at the Bfd binding site block the BfrB-Bfd complex, inhibit the mobilization of iron from BfrB in P. aeruginosa cells, elicit a bacteriostatic effect on planktonic cells, and are bactericidal to cells embedded in mature biofilms.

Scalable Total Synthesis of Piceatannol-3′-O-β-d-glucopyranoside and the 4′-Methoxy Congener Thereof: An Early Stage Glycosylation Strategy

Scalable syntheses of piceatannol-3'-O-β-D-glucopyranoside and the 4'-methoxy congener thereof were achieved. This route features an early implemented Fischer-like glycosylation reaction, a regioselective iodination of phenolic glycoside under strongly acidic conditions, a highly telescoped route to access the styrene derivative, and a key Mizoroki.Heck reaction to render the desired coupled products in high overall yield.

Total Synthesis of Two Glycosylated Stilbenes, Oxyresveratrol 2-O-β- d -Glucopyranoside and 2,3,5,4′-Tetrahydroxystilbene 2-O-β- d -Glucopyranoside

Glycosylated stilbenes are biologically active secondary metabolites of plants and have the potential to alleviate a broad range of human diseases. However, some of these compounds are not naturally abundant, and thus the synthesis of such molecules is de