18934-57-1Relevant articles and documents
Mechanochemical Encapsulation of Fullerenes in Peptidic Containers Prepared by Dynamic Chiral Self-Sorting and Self-Assembly
Szymański, Marek,Wierzbicki, Micha?,Gilski, Miros?aw,J?drzejewska, Hanna,Sztylko, Marcin,Cmoch, Piotr,Shkurenko, Aleksander,Jaskólski, Mariusz,Szumna, Agnieszka
supporting information, p. 3148 - 3155 (2016/03/23)
Molecular capsules composed of amino acid or peptide derivatives connected to resorcin[4]arene scaffolds through acylhydrazone linkers have been synthesized using dynamic covalent chemistry (DCC) and hydrogen-bond-based self-assembly. The dynamic character of the linkers and the preference of the peptides towards self-assembly into β-barrel-type motifs lead to the spontaneous amplification of formation of homochiral capsules from mixtures of different substrates. The capsules have cavities of around 800 ?3 and exhibit good kinetic stability. Although they retain their dynamic character, which allows processes such as chiral self-sorting and chiral self-assembly to operate with high fidelity, guest complexation is hindered in solution. However, the quantitative complexation of even very large guests, such as fullerene C60 or C70, is possible through the utilization of reversible covalent bonds or the application of mechanochemical methods. The NMR spectra show the influence of the chiral environment on the symmetry of the fullerene molecules, which results in the differentiation of diastereotopic carbon atoms for C70, and the X-ray structures provide unique information on the modes of peptide-fullerene interactions.
Decorating the lanthanide terminus of self-assembled heterodinuclear lanthanum(iii)/gallium(iii) helicates
Albrecht, Markus,Latorre, Irene,Mehmeti, Gent,Hengst, Konstantin,Oppel, Iris M.
experimental part, p. 12067 - 12074 (2012/01/14)
Arylacylhydrazones of 2,3-dihydroxybenzaldehyde are appropriate ligands for the preparation of heterodinuclear triple-stranded helicates involving high coordinated lanthanide(iii) ions. In the present study, three different kinds of substituents are intro
Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles
Bibian, Mathieu,Martinez, Jean,Fehrentz, Jean-Alain
body text, p. 7042 - 7049 (2011/10/04)
We report on the synthesis of 1,2,4-triazoles substituted with 2 or 3 amino acid side chains, using silver benzoate as a key reagent for the cyclization step. A complete study of the optical purity retention during the synthetic process leading to these c
Formamidine Ureas as Tunable Electrophiles
Diaz, David D.,Finn
, p. 303 - 309 (2007/10/03)
Formamidine urea compounds exchange imine fragments with primary nitrogen nucleophiles, allowing the preparation of a variety of derivatives from a single precursor. The reactivities of these species are governed primarily by the electron-donating power o
Azapeptides as inhibitors and active site titrants for cysteine proteinases
Xing, Ruye,Hanzlik, Robert P.
, p. 1344 - 1351 (2007/10/03)
Ester and amide derivatives of α-azaglycine (carbazic acid, H2NHCOOH), α-azaalanine, and α-azaphenylalanine (i.e., AC-L-Phe-NHN(R)CO-X, where X = H, CH3, or CH2Ph, respectively) were synthesized and evaluated as inhibitors
Cysteine protease inhibition by azapeptide esters
Magrath,Abeles
, p. 4279 - 4283 (2007/10/02)
Papain, a prototype cysteine protease, was inhibited in a time-dependent manner by azapeptide esters designed to deliver an azaglycine group to the active-site thiol. For example, the rate of inhibition was 18 M-1 s-1 for Ac-L-PheAgl
STUDIES ON THE KINETICS OF RACEMIZATION OF 2,4-DISUBSTITUTED-5(4H)-OXAZOLONES
Slebioda, Marek,St-Amand, Marc A.,Chen, Francis M. F.,Benoiton, N. Leo
, p. 2540 - 2544 (2007/10/02)
The kinetics of racemization of 2,4-disubstituted-5(4H)-oxazolones obtained from N-acetyl, N-benzoyl, and N-benzyloxycarbonylglycyl-L-leucine, -valine, and -phenylalanine have been studied in several solvents alone and in the presence of tertiary amines.T