191348-16-0

Basic information

• Product Name: FMOC-TYR(PO(OBZL)OH)-OH
• Synonyms: N-ALPHA-FMOC-O-BENZYL-L-PHOSPHOTYROSINE;Fmoc-Tyr(HPO3Bzl)-OH;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-2-BENZYL-L-PHOSPHOTYROSINE;N-alpha-(9-Fuorenylmethyloxycarbonyl)-2-benzyl-l-phosphotyrosine;Fmoc-Tyr[PO(OBzl)-OH;N-Fmoc-O-benzyl-L-phosphotyrosine;(2S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-(benzyloxy(hydroxy)phosphoryloxy)phenyl)propanoic acid;FMOC-O-BENZYL-L-PHOSPHOTYROSINE
• CAS NO: 191348-16-0
• Molecular Formula: C₃₁H₂₈NO₈P
• Molecular Weight: 573.53
• Product Categories: Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 191348-16-0.mol

Chemical Properties

• Appearance: Off-white to white/Powder
• Density: 1.378 g/cm³
• Refractive Index: 1.638
• Storage Temp.: -20°C
• Solubility: Soluble in 0.1g in 2mL DMF.
• PKA: 1.37±0.50(Predicted)
• CAS DataBase Reference: FMOC-TYR(PO(OBZL)OH)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-TYR(PO(OBZL)OH)-OH(191348-16-0)
• EPA Substance Registry System: FMOC-TYR(PO(OBZL)OH)-OH(191348-16-0)

Safety Data

• Hazardous Substances Data: 191348-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-TYR(PO(OBZL)OH)-OH is used as a pharmaceutical intermediate for the synthesis of various drugs. Its role in the industry is crucial as it aids in the development of new medications and therapies.
As a pharmaceutical intermediate, FMOC-TYR(PO(OBZL)OH)-OH is used for the following reasons:
1. It serves as a building block in the synthesis of complex drug molecules, allowing for the creation of a wide range of pharmaceuticals with diverse therapeutic applications.
2. Its chemical properties, such as being a white to off-white powder, make it suitable for use in the pharmaceutical industry, where purity and stability are essential.
3. The compound's versatility in chemical reactions enables the development of innovative drug candidates with improved efficacy, safety, and pharmacokinetic profiles.

InChI:InChI=1/C31H28NO8P/c33-30(34)29(18-21-14-16-23(17-15-21)40-41(36,37)39-19-22-8-2-1-3-9-22)32-31(35)38-20-28-26-12-6-4-10-24(26)25-11-5-7-13-27(25)28/h1-17,28-29H,18-20H2,(H,32,35)(H,33,34)(H,36,37)/t29-/m0/s1

Upstream product

• 134150-51-9 N²-<<(9H-Fluoren-9-yl)methoxy>carbonyl>-O⁴--L-tyrosine 
• 76101-29-6 benzyloxy dichlorophosphine 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1030021-96-5 C₂₈H₄₂N₅O₁₄P 
• 1030021-84-1 Ac-Tyr(PO₃H₂)-Glu-Thr-Leu-Gly-OH 

Relevant articles and documents

PROCESS FOR PREPARING PHOSPHORYLATED AMINO ACIDS

The present invention provides a short, safe, inexpensive, commercially scalable process for preparing a phosphorylated amino acid of Formula I, which can be performed in one pot without isolating any synthetic intermediates.

PROCESS FOR PREPARING PHOSPHORYLATED AMINO ACIDS

The present invention provides a short, safe, inexpensive, commercially scalable process for preparing a phosphorylated amino acid of Formula I, which can be performed in one pot without isolating any synthetic intermediates.

A general preparation of protected phosphoamino acids

Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.

Preparation and Use of Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine in Continuous Flow Solid Phase Peptide Synthesis

Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine is a useful derivative for the solid phase synthesis of O-phosphotyrosine peptides.