134150-51-9 Usage
General Description
FMOC-TYR(PO3BZL2)-OH is a compound consisting of a tyrosine residue with a phosphorylated benzyl ester group and a 9-fluorenylmethoxycarbonyl (FMOC) protecting group. The phosphorylated benzyl ester group acts as a phosphate mimic, making the compound useful in studying phosphorylation events in biological systems. The FMOC protecting group provides stability to the compound and allows for its selective deprotection during peptide synthesis. FMOC-TYR(PO3BZL2)-OH is commonly used in the field of biochemistry and peptide chemistry for the preparation of peptides and proteins with phosphorylated tyrosine residues, and it serves as a valuable tool for understanding and manipulating cellular signaling pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 134150-51-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,1,5 and 0 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 134150-51:
(8*1)+(7*3)+(6*4)+(5*1)+(4*5)+(3*0)+(2*5)+(1*1)=89
89 % 10 = 9
So 134150-51-9 is a valid CAS Registry Number.
InChI:InChI=1/C38H34NO8P/c40-37(41)36(39-38(42)44-26-35-33-17-9-7-15-31(33)32-16-8-10-18-34(32)35)23-27-19-21-30(22-20-27)47-48(43,45-24-28-11-3-1-4-12-28)46-25-29-13-5-2-6-14-29/h1-22,35-36H,23-26H2,(H,39,42)(H,40,41)/t36-/m0/s1
134150-51-9Relevant articles and documents
Preparation and Use of Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine in Continuous Flow Solid Phase Peptide Synthesis
Kitas, Eric A.,Wade, John D.,Johns, R. B.,Perich, John W.,Tregear, Geoffrey W.
, p. 338 - 339 (1991)
Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine is a useful derivative for the solid phase synthesis of O-phosphotyrosine peptides.
The synthesis of phosphopeptides via the Bpoc-based approach
Attard, Troy J.,Reynolds, Eric C.,Perich, John W.
, p. 664 - 670 (2008/03/27)
The 2-(p-biphenylyl)-2-propyloxycarbonyl (Bpoc) group was examined as an Nα-protecting group in the stepwise assembly of the MAP Kinase ERK2 [178-188; Thr(P)183, Tyr(P)185] peptide. The mild acid deprotection of the Bpoc group permitted (i) incorporation of a fully protected phosphothreonyl derivative and (ii) a TFA-based final cleavage step. The first five C-terminal residues (184-188) were incorporated in the Fmoc mode of peptide synthesis, with all subsequent amino acids coupled as their Bpoc-Xxx-OH derivatives. The target product was obtained in high purity and yield, indicating that a Bpoc-based approach to phosphopeptide synthesis was compatible with both the acid-labile side chain protecting groups employed and Hmp-Wang resin. This journal is The Royal Society of Chemistry.
