19281-31-3

Basic information

• Product Name: 2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE
• Synonyms: 2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE;2-Chloro-N-o-tolyl-propionaMide;2-Chloro-N-(o-tolyl)propanaMide;2-chloro-N-(2-methylphenyl)propionamide
• CAS NO: 19281-31-3
• Molecular Formula: C₁₀H₁₂ClNO
• Molecular Weight: 197.66
• Mol File: 19281-31-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE(19281-31-3)
• EPA Substance Registry System: 2-CHLORO-N-(2-METHYLPHENYL)PROPANAMIDE(19281-31-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 19281-31-3(Hazardous Substances Data)

Usage

Uses

2-Chloro-o-propionotoluidide (Prilocaine EP Impurity A) is an impurity of Prilocaine, a local anesthetic to treat paresthesia.

Upstream product

• 95-53-4 o-toluidine 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 10026-13-8 phosphorus pentachloride 
• 103028-87-1 DL-lactic acid o-toluidide 
• 71-43-2 benzene 
• 7623-09-8 2-chloropropionyl chloride 
• 120-66-1 N-(2-methylphenyl)acetamide 

Downstream Products

• 721-50-6 prilocaine 
• 1134193-54-6 2-methyl-4-o-tolyl-2H-1,4-benzoxazin-3(4H)-one 
• 60093-26-7 (5-methyl-4-oxo-3-o-tolyl-thiazolidin-2-ylidene)-cyanamide 

Relevant articles and documents

Preparation method of prilocaine base

The invention discloses a preparation method of prilocaine base. The method comprises the following steps: directly condensing 2-chloropropionic acid (formula V) and o-toluidine (formula IV) in the presence of chlorinated 4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholine to obtain N-(2-methyl phenyl)-2-chloride propionamide (formula III); reacting the N-(2-methyl phenyl)-2-chloride propionamide (formula III) with n-propylamine (formula II) in an acetone solvent in the presence of granular potassium carbonate to obtain a crude product of prilocaine base; and refining the prilocaine base to obtain medicine-grade prilocaine base (formula I). The method disclosed by the invention overcomes the shortcomings of the prior art and has the advantages of mild reaction conditions, no pollution, no equipment corrosion, good quality, high yield and convenient operation and is suitable for industrial production.