197291-75-1

Basic information

• Product Name: 9-Piperazino Ofloxacin
• Synonyms: 9-Piperazino Ofloxacin;Ofloxacin EP Impurity D;10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;Ofloxacin impurity D;(RS)-10-Fluoro-2,3-dihydro-3-methyl-9-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid;10-fluoro-3-methyl-9-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:1)
• CAS NO: 197291-75-1
• Molecular Formula: C18H20FN3O4
• Molecular Weight: 361.3675032
• Product Categories: Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 197291-75-1.mol

Chemical Properties

• Boiling Point: 588.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.48±0.1 g/cm3(Predicted)
• PKA: 5.28±0.40(Predicted)
• CAS DataBase Reference: 9-Piperazino Ofloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Piperazino Ofloxacin(197291-75-1)
• EPA Substance Registry System: 9-Piperazino Ofloxacin(197291-75-1)

Safety Data

• Hazardous Substances Data: 197291-75-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
9-Piperazino Ofloxacin is used as a degradation product for Ofloxacin, a widely used fluoroquinolone antibiotic. It is important to study and understand the properties and effects of this impurity to ensure the safety, efficacy, and quality of Ofloxacin-based medications.

Upstream product

• 82419-34-9 ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate 
• 82419-35-0 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid 
• 106939-34-8 ethyl (S)-(-)-9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-Pyrido[1,2,3-de]-[1,4]Benzoxazine-6-Carboxylate 

Relevant articles and documents

Preparation method of ofloxacin impurity D

The invention discloses a preparation method of ofloxacin impurity D, and belongs to the field of medicine synthesis. The preparation method has the advantages that the whole technology design is reasonable, the operability is strong, and the purifying is convenient. The preparation method is characterized in that oxygen-fluorine acid is used as an initiating raw material, and is performed with six-step reaction, so as to synthesize the ofloxacin impurity D. The ofloxacin impurity D prepared by the preparation method has the advantages that by screening the optimum preparation steps and reaction conditions through experiment, the purity can reach 99.5% or above; a testing sample is provided for the study of ofloxacin, and the important study value is realized in the clinical pharmacokinetic study.

Synthesis method of levofloxacin isomer compound

The invention provides a synthesis method of a levofloxacin isomer (-)-(S)-3-methyl-10-chloro-2, 3-dihydro-9-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridino-[1, 2, 3-de]-[1, 4] benzoxazine-6-carboxylic acid. The method comprises the following steps: a, preparation of a compound M1: taking levofloxacin acid ester as a raw material, and performing nitratlon reaction in a concentrated sulfuric acid, nitric acid or nitrate condition; b, preparation of a compound M2: adding N-methyl piperazine into the compound M1, so as to perform piperazine retraction reaction; c, preparation of a compound M3: reducing nitro in the compound M2 into amino with a reducing agent; d, preparation of a compound M4: converting the amino in the compound M3 into hydrogen atom; e, preparation of the levofloxacin isomer: performing esterolysis on the compound M4 in an acidic or alkaline condition. The invention provides a novel synthesis method of the levofloxacin isomer, thereby providing a preparation method of a comparison product for the quality research of levofloxacin, and further providing important guiding significance for the safe medication of levofloxacin.