82419-34-9

Basic information

• Product Name: Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate
• Synonyms: Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate;9, 10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid ethyl ester
• CAS NO: 82419-34-9
• Molecular Formula: C₁₅H₁₃F₂NO₄
• Molecular Weight: 309.2648264
• Mol File: 82419-34-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 261 °C(Solv: ethanol (64-17-5))
• Boiling Point: 442.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.62±0.60(Predicted)
• CAS DataBase Reference: Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate(82419-34-9)
• EPA Substance Registry System: Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate(82419-34-9)

Safety Data

• Hazardous Substances Data: 82419-34-9(Hazardous Substances Data)

Usage

General Description

Ethyl 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate is a chemical compound with the molecular formula C16H14F2N2O4. It is a derivative of quinoline and belongs to the oxazinoquinoline class of compounds. This chemical is commonly used in pharmaceutical research and is employed as a building block in the synthesis of various drugs. Its precise uses and properties may vary depending on the specific application, but its structural features make it an important intermediate in the development of new pharmaceutical compounds.

Upstream product

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• 90180-70-4 ethyl 9,10-difluoro-3-methylene-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzeneoxazine-6-carboxylate 
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• 86760-99-8 diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 82419-33-8 (-)-7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine 
• 94695-50-8 ethyl 3-(2,3,4,5-tetrafkuorophenyl)-3-oxopropanoate 
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• 94695-48-4 2,3,4,5-tetrafluorobenzoyl chloride 

Downstream Products

• 82419-36-1 ofloxacin 
• 131683-67-5 9-(3-Amino-pyrrolidin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 82419-52-1 N-Demethylofloxacin 
• 124338-73-4 9-(4-Ethyl-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 124255-93-2 8-Fluoro-3-methyl-6-oxo-9-(4-propyl-piperazin-1-yl)-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 86794-24-3 8-Fluoro-3-methyl-6-oxo-9-(4-phenyl-piperazin-1-yl)-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 86794-25-4 9-(4-Benzyl-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 178912-62-4 (3RS)-10-fluoro-3-methyl-9-(4- methylpiperazin-1-yl)-7-oxo-2,3-dihydro- 7Hpyrido[1,2,3-de]-1,4-benzoxazine-6- carboxylic acid 
• 82419-35-0 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid 

Relevant articles and documents

UTILISATION DU FLUORURE DE TETRABUTYLAMMONIUM COMME AGENT DE CYCLISATION DANS LA SYNTHESE D'ANTIBACTERIENS DERIVES D'ACIDE PYRIDONE-4-CARBOXYLIQUE-3

It has been found that the Bu4NF/THF base/solvent couple is very efficient in the key cyclization step of (2) to (5) in the synthesis of antibacterial pyridonecarboxylic acid derivatives.In particular chiral intermediate (2d) is directly converted in one

Preparation method of ofloxacin impurity D

The invention discloses a preparation method of ofloxacin impurity D, and belongs to the field of medicine synthesis. The preparation method has the advantages that the whole technology design is reasonable, the operability is strong, and the purifying is convenient. The preparation method is characterized in that oxygen-fluorine acid is used as an initiating raw material, and is performed with six-step reaction, so as to synthesize the ofloxacin impurity D. The ofloxacin impurity D prepared by the preparation method has the advantages that by screening the optimum preparation steps and reaction conditions through experiment, the purity can reach 99.5% or above; a testing sample is provided for the study of ofloxacin, and the important study value is realized in the clinical pharmacokinetic study.

STRUCTURAL MODIFICATION AND NEW METHODS FOR PREPARATION OF OFLOXACIN ANALOGS

Reaction of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate IIb with 2-amino-1-propanol provided corresponding compound IIIb which under alkaline conditions underwent an aromatic denitrocyclization reaction which after alkaline saponificat