2009-98-5

Basic information

• Product Name: Pentanoic acid, 2-diazo-3-oxo-, ethyl ester
• Synonyms: Pentanoic acid, 2-diazo-3-oxo-, ethyl ester
• CAS NO: 2009-98-5
• Molecular Formula: C₇H₁₀N₂O₃
• Molecular Weight: 170.1659
• Mol File: 2009-98-5.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pentanoic acid, 2-diazo-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 2-diazo-3-oxo-, ethyl ester(2009-98-5)
• EPA Substance Registry System: Pentanoic acid, 2-diazo-3-oxo-, ethyl ester(2009-98-5)

Safety Data

• Hazardous Substances Data: 2009-98-5(Hazardous Substances Data)

Usage

General Description

Pentanoic acid, 2-diazo-3-oxo-, ethyl ester is a chemical compound with the molecular formula C7H10N2O3. It is an ethyl ester derivative of pentanoic acid, and its structure contains a diazo group and a keto group. Pentanoic acid, 2-diazo-3-oxo-, ethyl ester is commonly used in organic synthesis as a diazo reagent, particularly in the formation of carbonyl compounds. It is a potentially hazardous and unstable compound that should be handled with caution due to its diazo functional group, which can be explosive under certain conditions. It is important to follow proper safety procedures and handling protocols when working with this chemical.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 79-03-8 propionyl chloride 
• 4949-44-4 ethyl propanoylacetate 
• 2158-14-7 4-acetamidobenzenesulfonyl azide 
• 941-55-9 4-toluenesulfonyl azide 
• 123-38-6 propionaldehyde 

Downstream Products

• 79388-03-7 ethyl 2-ethyl-4-oxo-4H-chromene-3-carboxylate 

Relevant articles and documents

Rh-Catalyzed Coupling of Acrylic/Benzoic Acids with α-Diazocarbonyl Compounds: An Alternative Route for α-Pyrones and Isocoumarins

A coupling of acrylic acids/benzoic acids with α-diazocarbonyl compounds has been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)2 additive. The presence of Zn(OAc)2 obviously accelerates the C(sp2)

Amino-modified Merrifield resins as recyclable catalysts for the safe and sustainable preparation of functionalized α-diazo carbonyl compounds

Amino-functionalized polystyrene polymers derived from Merrifield resins were prepared and characterized. These basic materials were successfully employed as heterogeneous catalysts in the diazo transfer reaction to 1,3-dicarbonyl compounds, furnishing the corresponding diazo compounds in good to excellent yields and in relatively short reaction times. In addition, the work-up and purification protocols are simple and do not generate large amounts of waste, which are important features in sustainable catalysis and environmentally benign processes. The feasibility of the recovery and reuse of the amino-modified catalysts was also verified, since they can be employed up to five times without appreciable loss of catalytic activity. This straightforward procedure can be readily scaled up to gram scale, enabling the wide application of this method. The synthetic potential was demonstrated through the two-step preparation of 2-amino-N-dodecylacetamide (ANDA), a small molecule of commercial relevance.

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE

The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclose