A corrosive irritant to
skin, eyes, and mucous membranes.
Dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidizing
materials. Reacts with water or steam to
produce toxic and corrosive fumes.
Exothermic reaction with diisopropyl ether
produces much gas. The reaction may be
dangerous if confmed. To fight fire, use
CO2, dry chemical; do not use water. When
heated to decomposition it emits lughly
toxic fumes of Cl-. See also
Propionyl chloride can be used as an acylating agent:
To convert anisole to 4-methoxypropiophenone and 2-methoxynaphthalene to 1-propio-2-methoxynaphthalene in the presence of Indium(III) chloride (InCl3) impregnated mesoporous Si-MCM-41 catalyst.
For chlorination in the presence of sulfuryl chloride and peroxides to form α-chloropropionyl chloride and β-chloropropionyl chloride.
In reaction with (hydroxypropyl)cellulose to form the propanoate ester, [(propionyloxy)propyl]cellulose.
Strong irritant to skin.
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
A colorless liquid with a pungent odor. Flash point of 50°F. Corrosive and very irritating to skin and eyes. Used to make other chemicals.
Acid halides, such as Propionyl chloride, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, and alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Air & Water Reactions
Highly flammable. Vigorously reacts with water to form propionic acid and hydrochloric acid [Merck 11th ed. 1989].