201334-88-5Relevant articles and documents
Synthesis and biological activity of N-substituted aminocarbonyl-1,3- dioxolanes as VLA-4 antagonists
Rehman, Abdul,Soni, Ajay,Naik, Keshav,Nair, Sreeji,Palle, Venkata P.,Dastidar, Sunanda,Ray, Abhijit,Alam,Salman, Mohammad,Cliffe, Ian A.,Sattigeri, Viswajanani
scheme or table, p. 5514 - 5520 (2011/01/12)
A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities.
A simple method for the alkaline hydrolysis of esters
Theodorou, Vassiliki,Skobridis, Konstantinos,Tzakos, Andreas G.,Ragoussis, Valentine
, p. 8230 - 8233 (2008/03/14)
A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed.