20357-20-4Relevant articles and documents
Friedlaender approach for the incorporation of 6-bromoquinoline into novel chelating ligands
Hu, Yi-Zhen,Zhang, Gang,Thummel, Randolph P.
, p. 2251 - 2253 (2003)
Nitration of 3-bromobenzaldehyde followed by sodium dithionite reduction provides 5-bromo-2-aminobenzaldehyde, which undergoes the Friedlaender condensation with a variety of enolizable ketones to afford bidentate and tridentate 6-bromoquinoline derivativ
o-Nitrobenzyl photoremovable groups with fluorescence uncaging reporting properties
Abou Nakad,Bolze,Specht
, p. 6115 - 6122 (2018/09/06)
o-Nitrobenzyl (o-NB) derivatives are the most widely applied photoremovable groups for the study of dynamic biological processes. By introducing different substituents to the benzylic position we were able to generate a fluorescence signal upon irradiatio
Triazole derivative having HSP90 (Heat Shock Protein) inhibiting activity, as well as preparation method and application of triazole derivative
-
Paragraph 0406; 0407; 0408; 0409, (2017/08/02)
The invention discloses a triazole derivative having an HSP90 (Heat Shock Protein) inhibiting activity, as well as a preparation method and an application of the triazole derivative. Specifically, the invention relates to the triazole derivative having a structure as shown in a formula (I), a stereisomer of the triazole derivative and a pharmaceutically acceptable salt, wherein the definition of each substituent group in the formula (I) and the definition in a description are the same. The compound with a novel structure has the HSP90 inhibiting activity, can be used to cure cancers, neurodegenerative disorders, inflammation diseases, autoimmune diseases, ischemic brain injuries and the like, and has a broad application prospect.